Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions
| العنوان: | Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions |
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| المؤلفون: | Chun-Hua Li, Jie Zhang, Ming-Fei Du, Yue-Yuan Liao, Ting Zou, Hao-Wei Zhou, Hao Li, Hao Jia, Chen Chen, Tie-Lin Yang, Dan Wang, Wei-Hua Gao, Yue Sun, Rui-Chen Yan, Xi Zhang, Ze-Jiaxin Niu, Ke-Ke Wang, Yang Wang, Ke Gao, Yu Yan, Chao Chu, Qiong Ma, Jianjun Mu, Xiao-Yu Zhang, Gui-Lin Hu, Shi Yao |
| المصدر: | The Journal of Clinical Hypertension |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Mean arterial pressure, hypertension, Tamm–Horsfall protein, gene polymorphism, uromodulin, Endocrinology, Diabetes and Metabolism, Urinary system, Renal function, Blood Pressure, Internal medicine, salt sensitivity, Genetics, Internal Medicine, medicine, Humans, salt, Sodium Chloride, Dietary, Salt intake, biology, business.industry, Diet, Sodium-Restricted, Pulse pressure, Endocrinology, Blood pressure, biology.protein, Original Article, Gene polymorphism, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Uromodulin, also named Tamm Horsfall protein, have been associated with renal function and sodium homeostasis regulation. The authors sought to examine the effects of salt intake on plasma and urinary uromodulin levels and the association of its genetic variants with salt sensitivity in Chinese adults. Eighty patients from our natural population cohort were maintained sequentially either on a usual diet for 3 days, a low‐salt diet (3.0 g) for 7 days, and a high‐salt diet (18.0 g) for an additional 7 days. In addition, the authors studied 514 patients of the Baoji Salt‐Sensitive Study, recruited from 124 families who received the same salt intake intervention, and investigated the association of genetic variations in uromodulin gene with salt sensitivity. Plasma uromodulin levels were significantly lower on a high‐salt diet than on a baseline diet (28.3 ± 4.5 vs. 54.9 ± 8.8 ng/ml). Daily urinary excretions of uromodulin were significantly decreased on a high‐salt diet than on a low‐salt diet (28.7 ± 6.7 vs. 157.2 ± 21.7 ng/ml). SNPs rs7193058 and rs4997081 were associated with the diastolic blood pressure (DBP), mean arterial pressure (MAP) responses to the high‐salt diet. In addition, several SNPs in the uromodulin gene were significantly associated with pulse pressure (PP) response to the low‐salt intervention. This study shows that dietary salt intake affects plasma and urinary uromodulin levels and that uromodulin may play a role in the pathophysiological process of salt sensitivity in the Chinese populations. |
| تدمد: | 1751-7176 1524-6175 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06984888dc40f54be84b37ae61e12deb https://doi.org/10.1111/jch.14347 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....06984888dc40f54be84b37ae61e12deb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17517176 15246175 |
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