Immune function in patients with acute pancreatitis
| العنوان: | Immune function in patients with acute pancreatitis |
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| المؤلفون: | Hiroshi Tomita, Yoshimura Tomita, Soichiro Uehara, Hiroshi Handa, Katsuhiro Gothoh |
| المصدر: | Journal of Gastroenterology and Hepatology. 18:363-370 |
| بيانات النشر: | Wiley, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Male, Interleukin 2, medicine.medical_specialty, Cellular immunity, CD8 Antigens, Lymphocyte, CD4-CD8 Ratio, Antineoplastic Agents, Severity of Illness Index, Fas ligand, Interferon-gamma, Th2 Cells, Adjuvants, Immunologic, Antigen, Internal medicine, medicine, Humans, Interferon gamma, fas Receptor, Aged, Immunity, Cellular, Hepatology, business.industry, Gastroenterology, Receptors, Interleukin-2, Middle Aged, Th1 Cells, medicine.disease, Interleukin-12, medicine.anatomical_structure, Endocrinology, Pancreatitis, Acute Disease, CD4 Antigens, Acute pancreatitis, Female, business, medicine.drug |
| الوصف: | Background: The aim of this study was to clarify the relationship between the balance of T-helper (Th)1 and Th2 cytokines, and the numbers of CD4+ T and CD8+ T-cells, and was investigated, together with the plasma concentration of the antigen, an apoptosis marker, in patients with mild and acute pancreatitis (AP). Methods: Plasma concentrations of soluble (s) CD4, sCD8, sIL-2-R, IL-12, IFN-γ and sFas antigen were measured by ELISA, and CD4+ T, and CD8+ T lymphocyte counts were measured by flow cytometry. Results: Both CD4+ T and CD8+ T-cells were reduced in number; in the severe cases the reduction in the former was more pronounced. A significant positive correlation was noted among the concentrations of sCD4, sIL-2-R and IL-12, and a significant positive correlation was also found between sCD4 and sFas. During the early stage of AP, the concentrations of sCD4, sCD8, sIL-2-R, IL-12 and IFN-γ increased more in the severe cases compared with those who had milder symptoms; however, these increases were moderated during the clinical course. Conclusion: We considered that these Th1 type CD4+ T cells probably induce the activation of macrophages and further pro-inflammatory reactions during the early stage of AP, as well as exerting direct cytotoxicity effects through Fas/Fas ligand expression. © 2003 Blackwell Publishing Asia Pty Ltd |
| تدمد: | 1440-1746 0815-9319 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cd9c3676afac107a56bea3b0e4c7ad https://doi.org/10.1046/j.1440-1746.2003.02979.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....06cd9c3676afac107a56bea3b0e4c7ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401746 08159319 |
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