Increased glutaminyl cyclase activity in brains of Alzheimer’s disease individuals
| العنوان: | Increased glutaminyl cyclase activity in brains of Alzheimer’s disease individuals |
|---|---|
| المؤلفون: | James A. Duce, Bruce X. Wong, Catriona McLean, Blaine R. Roberts, Peter J. Barnard, Adam P Gunn, Christopher Fowler |
| المصدر: | Journal of Neurochemistry. 156:979-987 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Databases, Factual, Amyloid beta, Qualitative evidence, Disease, Biochemistry, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Alzheimer Disease, Reference Values, Internal medicine, medicine, Humans, Enzyme Inhibitors, Life Style, Aged, Aged, 80 and over, Sex Characteristics, biology, business.industry, Monocyte, Australia, Brain, Middle Aged, Aminoacyltransferases, Enzyme assay, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, biology.protein, Biomarker (medicine), Female, Autopsy, Antibody, business, Biomarkers, 030217 neurology & neurosurgery, Glutaminyl cyclase activity |
| الوصف: | Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with Alzheimer's disease (AD). Reports of several-fold increases in soluble QC (sQC) expression in the brain and peripheral circulation of AD individuals has prompted the development of QC inhibitors as potential AD therapeutics. There is, however, a lack of standardized quantitative data on QC expression in human tissues, precluding inter-laboratory comparison and validation. We tested the hypothesis that QC is elevated in AD tissues by quantifying levels of sQC protein and activity in post-mortem brain tissues from AD and age-matched control individuals. We found a modest but statistically significant increase in sQC protein, which paralleled a similar increase in enzyme activity. In plasma samples sourced from the Australian Imaging, Biomarker and Lifestyle study we determined that QC activity was not different between the AD and control group, though a modest increase was observed in female AD individuals compared to controls. Plasma QC activity was further correlated with levels of circulating monocytes in AD individuals. These data provide quantitative evidence that alterations in QC expression are associated with AD pathology. |
| تدمد: | 1471-4159 0022-3042 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d9c9552cf2884f81bea2cfa18b4100 https://doi.org/10.1111/jnc.15114 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....06d9c9552cf2884f81bea2cfa18b4100 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14714159 00223042 |
|---|