Patients with Functional Dyspepsia Responding to Omeprazole Have a Characteristic Gastro-oesophageal Reflux Pattern
| العنوان: | Patients with Functional Dyspepsia Responding to Omeprazole Have a Characteristic Gastro-oesophageal Reflux Pattern |
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| المؤلفون: | R. Torp, Per G. Farup, S. Wetterhus, Øistein Hovde |
| المصدر: | Scandinavian Journal of Gastroenterology. 34:575-579 |
| بيانات النشر: | Informa UK Limited, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Randomization, Posture, Placebo, Gastroenterology, Double-Blind Method, Gastro, Internal medicine, medicine, Humans, Dyspepsia, Omeprazole, Aged, Helicobacter pylori, biology, business.industry, Esophageal disease, Reflux, Middle Aged, Anti-Ulcer Agents, medicine.disease, biology.organism_classification, Clinical trial, Treatment Outcome, Gastroesophageal Reflux, Female, business, medicine.drug |
| الوصف: | The effect of acid secretion inhibitors in patients with functional dyspepsia (FD) is equivocal. One previous trial showed an effect in patients with a characteristic gastro-oesophageal reflux pattern. This double-blind trial compares the number of reflux episodes in responders and non-responders to omeprazole.Twenty-four patients (men/women, 11:13; mean age, 49 years) with FD were included; those with reflux as the main symptom were excluded. An upper endoscopy and a 24-h oesophageal pH measurement were performed before randomization to treatment with 10-20 mg omeprazole or placebo for 4 weeks. Patients who at questioning considered themselves to have achieved sufficient relief of dyspeptic symptoms after 4 weeks were characterized as responders.The number of responders in the omeprazole and placebo groups was 8 of 14 (57%) and 2 of 10 (20%), respectively (P = 0.07). The mean number of reflux episodes at the 24-h oesophageal pH measurement in responders and non-responders to omeprazole was 57 and 25, respectively (P0.003). In the omeprazole group the number of responders was 0 of 5 (0%) in those with32 reflux episodes and 8 of 9 (89%) in those with32 reflux episodes (P0.003).Patients with FD responding to omeprazole were characterized by many reflux episodes. |
| تدمد: | 1502-7708 0036-5521 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070676b8f0a02c8d428b529c80def331 https://doi.org/10.1080/003655299750026029 |
| رقم الأكسشن: | edsair.doi.dedup.....070676b8f0a02c8d428b529c80def331 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15027708 00365521 |
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