Peripheral membrane proteins: Promising therapeutic targets across domains of life
| العنوان: | Peripheral membrane proteins: Promising therapeutic targets across domains of life |
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| المؤلفون: | Duncan G. G. McMillan, Deborah M Boes, Albert Godoy-Hernandez |
| المصدر: | Membranes, 11(5) Membranes Membranes, Vol 11, Iss 346, p 346 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Alternative oxidase, Drug targets, Filtration and Separation, TP1-1185, Review, Cell membrane, 03 medical and health sciences, Chemical engineering, 0302 clinical medicine, medicine, Chemical Engineering (miscellaneous), Electrostatic interactions, Hydrophobic membrane anchor, Chemistry, Peripheral membrane proteins, Chemical technology, Process Chemistry and Technology, Peripheral membrane protein, Human diseases, Periplasmic space, GPI-anchored proteins, Cell biology, 030104 developmental biology, Membrane, medicine.anatomical_structure, Membrane protein, 030220 oncology & carcinogenesis, Dihydroorotate dehydrogenase, Alkaline phosphatase, TP155-156 |
| الوصف: | Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydrophobic interactions, or directly, using hydrophobic tails or GPI-anchors. The nature of this interaction not only influences the location of the protein in the cell, but also the function. In addition to their unique relationship with the cell membrane, peripheral membrane proteins often play a key role in the development of human diseases such as African sleeping sickness, cancer, and atherosclerosis. This review will discuss the membrane interaction and role of periplasmic nitrate reductase, CymA, cytochrome c, alkaline phosphatase, ecto-5’-nucleotidase, acetylcholinesterase, alternative oxidase, type-II NADH dehydrogenase, and dihydroorotate dehydrogenase in certain diseases. The study of these proteins will give new insights into their function and structure, and may ultimately lead to ground-breaking advances in the treatment of severe diseases. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0375 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a851ba7d2609892914214ca818512b http://resolver.tudelft.nl/uuid:f138fbf1-20f7-4be3-8588-6e64ca6b3bbc |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....07a851ba7d2609892914214ca818512b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770375 |
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