Association of PD-1 and PDL-1 gene polymorphisms with colorectal cancer risk and prognosis
| العنوان: | Association of PD-1 and PDL-1 gene polymorphisms with colorectal cancer risk and prognosis |
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| المؤلفون: | Mehtap Cevik, Esat Namal, Ulkuhan Iner-Koksal, Nur Dinc-Sener, Atila Karaalp, Cavlan Ciftci, Belgin Susleyici |
| المساهمون: | Cevik M., Namal E., Iner-Koksal U., Dinc-Sener N., KARAALP A., Ciftci C., SÜSLEYİCİ B. |
| المصدر: | Molecular Biology Reports. 49:1827-1836 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Aging, Genotype, rs36084323, CELL LUNG-CANCER, TUMOR-CELLS, Clinical Biochemistry, rs2282055, Programmed Cell Death 1 Receptor, Life Sciences (LIFE), Molecular Biology and Genetics, Immune check point, CHILDREN, SUSCEPTIBILITY, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, PD-1/PD-L1, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, B7-H1 Antigen, PATHWAY, Structural Biology, BİYOKİMYA VE MOLEKÜLER BİYOLOJİ, Yaşam Bilimleri, Drug Discovery, PD-1, Genetics, BREAST-CANCER, Humans, PD1 GENE, Genetic Predisposition to Disease, Cytogenetic, Molecular Biology, Moleküler Biyoloji ve Genetik, INDUCED EXPRESSION, rs822336, Temel Bilimler, PDL-1, Life Sciences, General Medicine, Colorectal cancer, IMMUNE ESCAPE, MOLECULAR BIOLOGY & GENETICS, Yaşam Bilimleri (LIFE), Case-Control Studies, Natural Sciences, Colorectal Neoplasms, BIOCHEMISTRY & MOLECULAR BIOLOGY, Sitogenetik |
| الوصف: | Programmed Cell Death-1 (PD-1) together with Programmed Death Ligand 1 (PDL-1) have crucial roles in anti-tumor immune response, cancer susceptibility and prognosis. Since PD-1 and PDL-1 have been considered as important genetic risk factors in cancer development and their functions can be affected by polymorphic sites, we investigated the effects of PD-1 rs2227981, rs2227982, rs36084323 and PDL-1 rs2282055, rs822336 gene polymorphisms on colorectal cancer (CRC) risk and prognosis in Turkish subjects.Our study group consisted of 5-FU or Capacitabine prescribed CRC diagnosed patients and healthy controls. Genotype analyses of PD1 and PDL-1 polymorphisms were performed with Agena MassARRAY platform. rs36084323 CT genotype frequency was found to be higher in controls compared to cases (p 0.001). rs36084323 CT genotype was highly associated with reduced CRC risk compared to CC genotype (OR 0.068, 95% CI 0.022-0.211, p 0.001). In adjusted analysis, rs2282055 GG genotype was found to be associated with reduced CRC risk (OR 0.271, 95% CI 0.078-0.940, p = 0.040). rs2282055 TT genotype was found to be related to longer progression-free (Bonferroni corrected Log rank p = 0.013) and overall survival (Bonferroni corrected Log rank p = 0.009) to that of GG genotypes. Patients with rs822336 GC+CC genotypes showed longer overall survival times compared to GG (Log rank p = 0.044).According to our results, PD-1 rs822336 G C polymorphism might be useful in predicting CRC prognosis. PDL-1 rs2282055 T G polymorphism might be useful in predicting both CRC risk and prognosis. Further studies should be conducted in larger and different populations to clear the roles of PD-1 and PDL-1 polymorphisms in CRC risk and prognosis. |
| وصف الملف: | application/pdf |
| تدمد: | 1573-4978 0301-4851 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ab9767a0d5b20479033ca54a08109f https://doi.org/10.1007/s11033-021-06992-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....07ab9767a0d5b20479033ca54a08109f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15734978 03014851 |
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