Clinical Validation of Eye Vergence as an Objective Marker for Diagnosis of ADHD in Children
| العنوان: | Clinical Validation of Eye Vergence as an Objective Marker for Diagnosis of ADHD in Children |
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| المؤلفون: | Josep Antoni Ramos-Quiroga, Alba Capdevila, Alexandre Perera I Lluna, Maria Solé Puig, Hans Supèr, José Cañete, Paloma Varela Casal, Flavia Lorena Esposito, Nuria de la Osa, Imanol Morata Martínez, Stephen V. Faraone, Lourdes Ezpeleta |
| المساهمون: | Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya. B2SLab - Bioinformatics and Biomedical Signals Laboratory |
| المصدر: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| بيانات النشر: | SAGE Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], medicine.medical_specialty, Adolescent, Infants amb trastorns del desenvolupament, diagnosis, Trastorn per dèficit d'atenció i hiperactivitat, Vergence, eye vergence, behavioral disciplines and activities, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, children, mental disorders, Developmental and Educational Psychology, medicine, Humans, ADHD, 0501 psychology and cognitive sciences, Child, 05 social sciences, Reproducibility of Results, Attention-deficit hyperactivity disorder--Diagnosis, Convergence, Ocular, Clinical Psychology, Attention Deficit Disorder with Hyperactivity, Oculomotor control, Case-Control Studies, biomarker, binocular, Biomarker (medicine), Psychology, Biomarkers, 030217 neurology & neurosurgery, 050104 developmental & child psychology |
| الوصف: | Objective: ADHD youth show poor oculomotor control. Recent research shows that attention-related eye vergence is weak in ADHD children. Method: To validate vergence as a marker to classify ADHD, we assessed the modulation in the angle of vergence of children ( n = 43) previously diagnosed with ADHD while performing an attention task and compared the results with age-matched clinical controls ( n = 19) and healthy peers ( n = 30). Results: We observed strong vergence responses in healthy participants and weak vergence in the clinical controls. ADHD children showed no significant vergence responses. Machine-learning models classified ADHD patients ( n = 21) from healthy controls ( n = 21) with an accuracy of 96.3% (false positive [FP]: 5.12%; false negative [FN]: 0%; area under the curve [AUC]: 0.99) and ADHD children ( n = 11) from clinical controls ( n = 14) with an accuracy of 85.7% (FP: 4.5%; FN: 19.2%, AUC: 0.90). Conclusion: In combination with an attention task, vergence responses can be used as an objective marker to detect ADHD in children. |
| وصف الملف: | application/pdf |
| تدمد: | 1557-1246 1087-0547 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cf92a0ff77b8a00efc0e0382a92b01 https://doi.org/10.1177/1087054717749931 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....07cf92a0ff77b8a00efc0e0382a92b01 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15571246 10870547 |
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