Cellular self-organization: generating order from the abyss
| العنوان: | Cellular self-organization: generating order from the abyss |
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| المؤلفون: | Derek McCusker |
| المساهمون: | Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Molecular Biology of the Cell Molecular Biology of the Cell, American Society for Cell Biology, 2020, 31 (3), pp.143-148. ⟨10.1091/mbc.E19-04-0207⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | rho GTP-Binding Proteins, Cells, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Cellular level, Cell Physiological Phenomena, GTP Phosphohydrolases, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, Molecular Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Self-organization, 0303 health sciences, Cell Membrane, Cell Biology, Lipid Metabolism, Lipids, Actins, Living systems, Order (biology), Perspective, Anisotropy, Thermodynamics, Biochemical engineering, 030217 neurology & neurosurgery |
| الوصف: | While the organization of inanimate systems such as gases or liquids is predominantly thermodynamically driven-a mixture of two gases will tend to mix until they reach equilibrium-biological systems frequently exhibit organization that is far from a well-mixed equilibrium. The anisotropies displayed by cells are evident in some of the dynamic processes that constitute life including cell development, movement, and division. These anisotropies operate at different length-scales, from the meso- to the nanoscale, and are proposed to reflect self-organization, a characteristic of living systems that is becoming accessible to reconstitution from purified components, and thus a more thorough understanding. Here, some examples of self-organization underlying cellular anisotropies at the cellular level are reviewed, with an emphasis on Rho-family GTPases operating at the plasma membrane. Given the technical challenges of studying these dynamic proteins, some of the successful approaches that are being employed to study their self-organization will also be considered. |
| اللغة: | English |
| تدمد: | 1939-4586 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd5882266923f909dc317ae98dce5f https://hal.archives-ouvertes.fr/hal-03103580/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....07dd5882266923f909dc317ae98dce5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19394586 |
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