KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han
| العنوان: | KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han |
|---|---|
| المؤلفون: | Si Qi Cai, Jia Cai Zhuo, Yuan Tao Chen, Zhi Chao Yang, Jian Xin Zhen, Zhihui Deng |
| المصدر: | BioMed Research International, Vol 2020 (2020) BioMed Research International |
| بيانات النشر: | Hindawi Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, China, Adolescent, Genotype, Article Subject, chemical and pharmacologic phenomena, Human leukocyte antigen, Biology, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Asian People, hemic and lymphatic diseases, otorhinolaryngologic diseases, medicine, Humans, Receptor, Gene, Aged, Genetic association, Aged, 80 and over, General Immunology and Microbiology, Myelodysplastic syndromes, Receptors, KIR3DL1, hemic and immune systems, General Medicine, Middle Aged, medicine.disease, HLA-B Antigens, Myelodysplastic Syndromes, 030220 oncology & carcinogenesis, Immunology, Medicine, Female, KIR3DL1, Research Article, 030215 immunology |
| الوصف: | Background. The association studies of killer cell immunoglobulin-like receptors (KIRs) with the occurrence of myelodysplastic syndromes (MDS) are limited worldwide; this study investigated the genetic risk/protective factors of MDS in KIR and human leucocyte antigen (HLA) systems to gain a better understanding of the role played by KIR and their cognate HLA ligands in MDS pathogenesis. Methods. We genotyped a total number of 77 patients with MDS from Chinese Southern Han and 745 healthy controls for the KIR loci and HLA class I. The carrier frequencies of KIR genes, KIR genotypes, class I HLA ligands, and KIR-HLA combinations were calculated by direct counting. The effect of individual KIR genes and HLA ligands on MDS risk was evaluated by logistic regression analyses using SAS 9.2 software. Results. We found that neither the KIR genes nor the KIR genotypes were associated with the occurrence of MDS. However, we observed that the frequencies for the strong inhibitory ligand HLA-Bw4 as well as KIR3DL1-HLA-Bw4 combination were significantly higher in healthy controls than those in the MDS patient group, respectively (73.42% vs. 62.34%, P=0.038; 70.87% vs. 59.74%, P=0.043). Conclusion. Our results showed that HLA-Bw4 ligand and KIR3DL1-HLA-Bw4 combination could confer a protective effect against MDS in Chinese Southern Han. |
| وصف الملف: | text/xhtml |
| تدمد: | 2314-6141 2314-6133 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0846a5a6e90ee6c07b2fb66cb3774a46 https://doi.org/10.1155/2020/6215435 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0846a5a6e90ee6c07b2fb66cb3774a46 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
|---|