The poly(A) polymerase beta gene may not be associated with azoospermia caused by Sertoli-cell-only syndrome in Japanese patients by comparing patients and normal controls
| العنوان: | The poly(A) polymerase beta gene may not be associated with azoospermia caused by Sertoli-cell-only syndrome in Japanese patients by comparing patients and normal controls |
|---|---|
| المؤلفون: | Kazuo Sengoku, Toshinobu Miyamoto, Masashi Iijima, Gaku Minase, Hiroshi Okada, Takeshi Shin, Yasuaki Saijo |
| المصدر: | Journal of Obstetrics and Gynaecology. 39:434-436 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Polymorphism, Single Nucleotide, Male infertility, Andrology, Sertoli cell-only syndrome, Mice, 03 medical and health sciences, 0302 clinical medicine, Asian People, Japan, Animals, Humans, Medicine, Gene, DNA Polymerase beta, Polymerase, Azoospermia, Retrospective Studies, 030219 obstetrics & reproductive medicine, Male factor, biology, Sertoli Cell-Only Syndrome, business.industry, Obstetrics and Gynecology, medicine.disease, Poly(A) Polymerase Beta, Cytoplasm, Case-Control Studies, 030220 oncology & carcinogenesis, biology.protein, business |
| الوصف: | Approximately 15% of couples are infertile, with half of these cases being due to a male factor. Testis-specific cytoplasmic poly(A) polymerase beta (PAPOLB) is known to be critical for spermatogenesis. In mice, the loss of function of the Papolb gene results in the arrest of spermiogenesis and in male infertility. To analyse the role of the PAPOLB gene in human male infertility, this study investigated the relevance of this gene to human Sertoli-cell-only syndrome (SCOS) with azoospermia. Mutation analysis of the PAPOLB coding region was performed on 139 Japanese patients by PCR and direct sequence analysis. No critical mutations directly causing SCOS were detected, but three single-nucleotide polymorphisms (SNPs; SNP1 (c1101C T), SNP2 (c1347T C) and SNP3 (c1903C A)) were found in the coding region. However, there were no significant associations in the allelic and genotypic distributions of these three SNPs between the SCOS and control groups (p.05). This study suggests a lack of association of PAPOLB with azoospermia due to SCOS in humans. |
| تدمد: | 1364-6893 0144-3615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0870221d0ecae7aaaaa7270313109e92 https://doi.org/10.1080/01443615.2018.1504205 |
| رقم الأكسشن: | edsair.doi.dedup.....0870221d0ecae7aaaaa7270313109e92 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 13646893 01443615 |
|---|