A comparison of the effects of an alpha-agonist, an anti-muscarinic agent and placebo on intranasal histamine challenge in allergic rhinitis
| العنوان: | A comparison of the effects of an alpha-agonist, an anti-muscarinic agent and placebo on intranasal histamine challenge in allergic rhinitis |
|---|---|
| المؤلفون: | R. W. Fuller, N. B. Pride, J. C. Henderson, M. A. Birchall |
| المصدر: | Clinical Otolaryngology. 21:212-217 |
| بيانات النشر: | Wiley, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_treatment, Cholinergic Agents, Scopolamine Derivatives, Mucous membrane of nose, Sodium Chloride, Pharmacology, Xylometazoline, chemistry.chemical_compound, Histamine Agents, Muscarinic acetylcholine receptor, Humans, Medicine, Saline, Dose-Response Relationship, Drug, business.industry, Imidazoles, Rhinitis, Allergic, Seasonal, Middle Aged, Otorhinolaryngology, chemistry, Immunology, Female, Nasal administration, Nasal Lavage Fluid, business, Adrenergic alpha-Agonists, Oxitropium bromide, Histamine, medicine.drug |
| الوصف: | Autonomic receptors play a part in the physiology and pathology of the nasal mucosa. The effect of an alpha-agonist and an anti-muscarinic agent on histamine-challenge was examined on patients with perennial allergic rhinitis. Nine patients received saline, oxitropium bromide 0.075%, or xylometazoline hydrochloride 0.1% in a double-blind fashion. Sequential challenge with increasing doses of histamine were given and resistance changes, sneezes and volume and content of secretion measured. Histamine challenge produced dose-related increases in nasal resistance (P < 0.0001), lavage fluid volume (P < 0.01) and total protein (P < 0.01). Following xylometazoline, histamine produced little increase in resistance compared with saline and oxitropium bromide (P < 0.0001). The latter reduced the dose-related increase in resistance (P < 0.01) and nasal lavage fluid volume (P = 0.0007) and total protein (P = 0.023) seen with saline. These results confirm the importance of alpha-adrenergic and muscarinic receptors in the human nasal mucosa and suggest mechanisms of action for these drugs in perennial allergic rhinitis. |
| تدمد: | 1749-4486 1749-4478 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0886712c37cd7d1240cb889b1b93c706 https://doi.org/10.1111/j.1365-2273.1996.tb01727.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0886712c37cd7d1240cb889b1b93c706 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17494486 17494478 |
|---|