Heterogeneous visceral nerve changes in acrylamide intoxication
| العنوان: | Heterogeneous visceral nerve changes in acrylamide intoxication |
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| المؤلفون: | Nora Frontali, Doris Dahl, M. Sbraccia, Gian-Luca Ferri, S. Zareh, Luigi Abelli |
| المصدر: | Experimental Brain Research. 87 |
| بيانات النشر: | Springer Science and Business Media LLC, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Neurofilament, Diaphragm, Urinary Bladder, Immunocytochemistry, Population, Fluorescent Antibody Technique, Bronchi, Autonomic Nervous System, Eye, Nerve Fibers, Neurofilament Proteins, Tubulin, Cornea, medicine, Animals, education, Intermediate filament, Neurons, Acrylamide, Acrylamides, Afferent Pathways, education.field_of_study, Glial fibrillary acidic protein, biology, Chemistry, General Neuroscience, Rats, Inbred Strains, Anatomy, Rats, Trachea, Autonomic nervous system, medicine.anatomical_structure, Peripheral nervous system, biology.protein, Ureter, Digestive System |
| الوصف: | A variety of visceral nerves were studied by intermediate filament immunocytochemistry in rats intoxicated with acrylamide. In such animals, oesophageal and diaphragmatic motor end-plates were invaded and deformed by neurofilament protein-like material, while afferent fibres of diaphragmatic neuromuscular spindles and myelinated sensory fibres of the iris showed striking terminal accumulation of similar material. Conversely, the rich population of thin afferent fibres of the iris showed no obvious abnormality, while pre-terminal changes were seen along the extrinsic nerve fibres supplying the cornea and myenteric ganglia. Multiple lesions were demonstrated in gut nerves of acrylamide-treated rats, while scattered “enteric glial cells” showed abnormally coarse morphology and a striking increase in glial fibrillary acidic protein immunoreactivity. A distinct, delicately varicose appearence was revealed by neurofilament protein-immunostaining in bladder nerve fibres of normal rats, which was changed to one of coarse dilations by acrylamide. In conclusion, apparently selective changes were found along different types of axons, in dicating marked heterogeneity in cytoskeletal organisation among visceral nerves. Taken together with the proposed inhibition by acrylamide of neurofilament proteins degradation, the above findings may suggest a non-uniform distribution of neurofilament degradation sites along distal regions of different axons. |
| تدمد: | 1432-1106 0014-4819 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b3053086a87994f1841e2d5d684d94 https://doi.org/10.1007/bf00231853 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....08b3053086a87994f1841e2d5d684d94 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321106 00144819 |
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