Immune factors associated with the pathological and therapeutic effects of preoperative chemotherapy in patients with breast cancer
| العنوان: | Immune factors associated with the pathological and therapeutic effects of preoperative chemotherapy in patients with breast cancer |
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| المؤلفون: | Kensuke Kawasaki, Sayaka Sawada, Megumi Wakisaka, Ryungsa Kim, Yukitaka Morita, Takanori Kin, Mika Shimoyama, Mitsuya Ito, Ami Kawai, Shoichiro Ohtani, Masayuki Hidaka, Koji Arihiro, Naomi Yasuda |
| المصدر: | Translational Oncology, Vol 14, Iss 1, Pp 100927-(2021) Translational Oncology |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, chemical and pharmacologic phenomena, Immune factor, lcsh:RC254-282, Metastasis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, Breast cancer, Internal medicine, medicine, Original Research, Chemotherapy, Tumor microenvironment, business.industry, Therapeutic effect, Cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Pathological and therapeutic effects, Vascular endothelial growth factor, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Preoperative chemotherapy, business |
| الوصف: | Highlights • The immune factors that determine the pathological and therapeutic effects of preoperative chemotherapy in patients with breast cancer are associated with local and systemic immune responses in the presence of tumor-infiltrating lymphocytes, in collaboration with downregulation of immunosuppressive factors mediated by vascular endothelial growth factor (VEGF) and cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulatory T cells (Tregs) in the tumor microenvironment. • Multivariate analysis showed that grade 2 and better therapeutic effects tended to be associated with higher natural killer cell levels after preoperative chemotherapy (odds ratio = 1.02; 95% confidence interval, 0.99–1.05; p = 0.07). • Therapy targeting VEGF and CTLA-4 in Tregs to overcome tumor-derived immunosuppression may enhance the pathological and therapeutic responses to preoperative chemotherapy in patients with breast cancer. Immune activation plays an important role in achieving the pathological and therapeutic effects of preoperative chemotherapy in patients with breast cancer. We evaluated how the immune response contributes to various therapeutic effects. This study was conducted on 43 patients with stages II–IV breast cancer who received preoperative chemotherapy followed by surgery. Peripheral natural killer (pNK) cell activity and the neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, and platelet-lymphocyte ratio (PLR) were assessed before and after chemotherapy. Tumor-infiltrating lymphocytes (TILs) and levels of 14 tumor microenvironmental factors, analyzed by next-generation sequencing, were assessed in formalin-fixed, paraffin-embedded sections of preoperative biopsy samples and surgical specimens. Univariate analysis showed that grade 2 (G2) and better therapeutic effects were significantly associated with human epidermal growth factor receptor 2 (HER-2)-positive cancer, lower PLRs, and higher NK cell and interleukin-6 levels after chemotherapy. The disappearance of axillary lymph-node metastasis was significantly associated with HER-2-positive cancer; increased pNK cell activity and lower PLRs and vascular endothelial growth factor (VEGF) levels after chemotherapy; and increased cytotoxic T lymphocyte antigen 4 (CTLA-4) levels in regulatory T cells (Tregs) and ≥5% TILs before chemotherapy. Multivariate analysis showed that G2 and better therapeutic effects tended to be associated with higher NK cell levels after chemotherapy (odds ratio = 1.02; 95% confidence interval, 0.99–1.05; P = 0.07). The activation of local and systemic immune responses by downregulation of immunosuppressive factors, such as VEGF and CTLA-4 in Tregs, had variable pathological and therapeutic effects after preoperative chemotherapy in patients with breast cancer. |
| اللغة: | English |
| تدمد: | 1936-5233 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d3b4a435a84579733ef9a77dfda91c http://www.sciencedirect.com/science/article/pii/S1936523320304198 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....08d3b4a435a84579733ef9a77dfda91c |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 19365233 |
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