Dopamine receptor agonist rotigotine-loaded microspheres ameliorates sexual function deteriorated by fluoxetine in depression rats
| العنوان: | Dopamine receptor agonist rotigotine-loaded microspheres ameliorates sexual function deteriorated by fluoxetine in depression rats |
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| المؤلفون: | Fenghua Fu, Yiqian Fan, Shumin Yue, Tian Wang, Leiming Zhang, Yunqi Yang, Ce Zhang, Rongxia Liu, Wenqian Wang |
| المصدر: | ASN NEURO ASN Neuro, Vol 13 (2021) |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Agonist, medicine.medical_specialty, Tetrahydronaphthalenes, medicine.drug_class, Neurosciences. Biological psychiatry. Neuropsychiatry, Thiophenes, Dopamine agonist, Dopamine, Internal medicine, medicine, Animals, Humans, Fluoxetine, business.industry, Depression, General Neuroscience, fluoxetine, Rotigotine, Original Papers, Microspheres, Rats, Endocrinology, Dopamine receptor, bilateral olfactory bulbectomy, sexual dysfunction, Dopamine Agonists, rotigotine-loaded microspheres, Antidepressant, Neurology (clinical), Sexual function, business, medicine.drug, RC321-571 |
| الوصف: | Low dopamine levels may cause depressive symptoms. Dopamine is also involved in sexual behavior. Rotigotine is a nonergolinic dopamine agonist. Fluoxetine, an antidepressant that acts as a selective serotonin (5-HT) reuptake inhibitor, may cause moderate or severe sexual dysfunction. This study aims to investigate the effects of rotigotine-loaded microspheres (RoMS) and rotigotine on fluoxetine-induced impairment of sexual function and their efficacy in depression-model rats. Rats with depressive-like behavior, induced by bilateral olfactory bulbectomy, were treated intragastrically with fluoxetine and co-administered RoMS or rotigotine subcutaneously. Then, copulatory behavior and open field tests were conducted. Serum luteinizing hormone and testosterone levels were assayed with enzyme-linked immunosorbent assay kits. The concentrations of 5-HT, dopamine, and norepinephrine were measured in the raphe nucleus and amygdala. The results showed that sexual function was decreased in olfactory bulbectomy rats and significantly deteriorated by fluoxetine. Co-administration of RoMS partly reversed the fluoxetine-induced impairment of sexual function, but rotigotine administration did not produce any improvement. Hyperactivity in olfactory bulbectomy rats was significantly attenuated by fluoxetine but was not influenced by co-administration of RoMS. Compared with the fluoxetine group, RoMS increased the testosterone, luteinizing hormone, dopamine, and norepinephrine levels. These findings indicated that RoMS improved the fluoxetine-induced impairment of sexual function and did not affect its antidepressant efficacy in depressive rats, which provides a potential treatment for patients with depression that can reduce the possibility of sexual dysfunction. Additionally, co-administration of fluoxetine with RoMS may be beneficial for Parkinson's disease patients with depression. |
| اللغة: | English |
| تدمد: | 1759-0914 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090e824e4784f8b7e7ad5ecb1eff22e6 http://europepmc.org/articles/PMC8819804 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....090e824e4784f8b7e7ad5ecb1eff22e6 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17590914 |
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