Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
| العنوان: | Closed-loop stimulation of temporal cortex rescues functional networks and improves memory |
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| المؤلفون: | Daniel S. Rizzuto, Joel M. Stein, Michael R. Sperling, Kathryn A. Davis, Richard Gorniak, Barbara C. Jobst, Bradley C. Lega, Ashwini Sharan, Mark A. Gorenstein, Gregory A. Worrell, Robert E. Gross, Sandhitsu R. Das, Deborah F. Levy, Michael J. Kahana, Allison Kadel, Isaac Pedisich, Paul A. Wanda, Alexis Burks, Youssef Ezzyat, Michal T. Kucewicz, Ada Aka, Cory S. Inman |
| المصدر: | Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018) Nature Communications |
| بيانات النشر: | Nature Portfolio, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Memory Dysfunction, Brain activity and meditation, Computer science, Science, General Physics and Astronomy, Hippocampus, Brain mapping, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Memory, Encoding (memory), Humans, lcsh:Science, Temporal cortex, Brain Mapping, Multidisciplinary, Recall, Long-term memory, fungi, Brain, food and beverages, General Chemistry, Middle Aged, Magnetic Resonance Imaging, Electric Stimulation, Temporal Lobe, 030104 developmental biology, Epilepsy, Temporal Lobe, lcsh:Q, Electrocorticography, Nerve Net, Neuroscience, 030217 neurology & neurosurgery, Psychomotor Performance |
| الوصف: | Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction. Memory lapses can occur due to ineffective encoding, but it is unclear if targeted brain stimulation can improve memory performance. Here, authors use a closed-loop system to decode and stimulate periods of ineffective encoding, showing that stimulation of lateral temporal cortex can enhance memory. |
| اللغة: | English |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0911efae5d2f95253218286520f00240 https://doaj.org/article/d56189e621fb48bc91fd7d8dd42fe5f0 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0911efae5d2f95253218286520f00240 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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