Potential variables affecting the quality of animal studies regarding pathophysiology of traumatic spinal cord injuries
| العنوان: | Potential variables affecting the quality of animal studies regarding pathophysiology of traumatic spinal cord injuries |
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| المؤلفون: | Mahdi Sharif-Alhoseini, Motahareh Rezvan, Zahra Hassannejad, Soheil Saadat, Mona Mokhatab, Aida Shakouri-Motlagh, Shayan Abdollah Zadegan, F Vahedi, Vafa Rahimi-Movaghar, Farhad Shokraneh |
| المصدر: | Spinal Cord. 54:579-583 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Delphi Technique, education, Delphi method, Validity, 03 medical and health sciences, 0302 clinical medicine, Cohen's kappa, Species Specificity, Cronbach's alpha, Surveys and Questionnaires, medicine, Animals, Humans, 030212 general & internal medicine, Psychiatry, Spinal Cord Injuries, Reliability (statistics), Trauma Severity Indices, business.industry, Reproducibility of Results, General Medicine, Focus group, Checklist, Disease Models, Animal, Neurology, Physical therapy, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Kappa |
| الوصف: | This is a Delphi study. Defining variables that potentially influence the outcomes of an animal study regarding pathophysiology of traumatic spinal cord injury (TSCI). This study was conducted in Iran. A modified two-round Delphi study was conducted. As the first round, an initial questionnaire was developed on the basis of literature and a series of focus group discussions. In the second round, the participants were asked to score the items through a 10-point scale. Consensus was achieved through the following criteria: (1) the median of scores has to be at 7.5 or higher, and (2) at least 70% of participants need to rate 7 or higher. Also, the inter-rater reliability analysis was performed to determine consistency among raters using the Kappa coefficient and Cronbach's alpha. Twenty-one experts participated in our study. From the first round of the study, a 47-item checklist was developed. By considering the aforementioned criteria for consensus building on extremely important factors, we reached a 15-item checklist including species, strain, method and level of injury, control group, genetic background, severity of injury, attrition, use of appropriate test, blindness, method of allocation to treatments, regulation and ethics, age/weight, bladder expression, number of animals/group and statistics. The inter-rater reliability for the raters was found to be Kappa=0.82 (P |
| تدمد: | 1476-5624 1362-4393 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09280c38396d2344fe4b77dbd0b34432 https://doi.org/10.1038/sc.2015.215 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....09280c38396d2344fe4b77dbd0b34432 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765624 13624393 |
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