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Effect of awake craniotomy in glioblastoma in eloquent areas (GLIOMAP)

التفاصيل البيبلوغرافية
العنوان: Effect of awake craniotomy in glioblastoma in eloquent areas (GLIOMAP)
المؤلفون: Jasper K W Gerritsen, Rosa H Zwarthoed, John L Kilgallon, Noah L Nawabi, Charissa A C Jessurun, Georges Versyck, Koen P Pruijn, Fleur L Fisher, Emma Larivière, Lien Solie, Rania A Mekary, Djaina D Satoer, Joost W Schouten, Eelke M Bos, Alfred Kloet, Rishi Nandoe Tewarie, Timothy R Smith, Clemens M F Dirven, Steven De Vleeschouwer, Marike L D Broekman, Arnaud J P E Vincent
المساهمون: Neurosurgery
المصدر: The Lancet Oncology, 23(6), 802-817. Lancet Publishing Group
بيانات النشر: Lancet Publishing Group, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Aged, 80 and over, Cohort Studies, Oncology, Brain Neoplasms, Humans, Female, Wakefulness, Glioblastoma, Propensity Score, Craniotomy, Aged, Retrospective Studies
الوصف: Background: Awake mapping has been associated with decreased neurological deficits and increased extent of resection in eloquent glioma resections. However, its effect within clinically relevant glioblastoma subgroups remains poorly understood. We aimed to assess the benefit of this technique in subgroups of patients with glioblastomas based on age, preoperative neurological morbidity, and Karnofsky Performance Score (KPS). Methods: In this propensity score-matched analysis of an international, multicentre, cohort study (GLIOMAP), patients were recruited at four tertiary centres in Europe (Erasmus MC, Rotterdam and Haaglanden MC, The Hague, Netherlands, and UZ Leuven, Leuven, Belgium) and the USA (Brigham and Women's Hospital, Boston, MA). Patients were eligible if they were aged 18–90 years, undergoing resection, had a histopathological diagnosis of primary glioblastoma, their tumour was in an eloquent or near-eloquent location, and they had a unifocal enhancing lesion. Patients either underwent awake mapping during craniotomy, or asleep resection, as per treating physician or multidisciplinary tumour board decision. We used propensity-score matching (1:3) to match patients in the awake group with those in the asleep group to create a matched cohort, and to match patients from subgroups stratified by age (
اللغة: English
تدمد: 1474-5488
1470-2045
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0930a68abc3acf3f0f557171159d210e
https://doi.org/10.1016/S1470-2045(22)00213-3
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....0930a68abc3acf3f0f557171159d210e
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14745488
14702045