Background: Understanding of predictive factors for tobacco use initiation among adolescents is critical for effective intervention and prevention. In this regard, we aimed to determine the profile, examine associated factors, and show the regional disparities in the use of tobacco products among the youth in Ghana. Method: The study used the 2017 Ghana Global Youth Tobacco Survey (GYTS) to obtain tobacco-related information among adolescents in Junior High Schools across the country. The study used a 2-stage cluster randomized sampling technique to obtain nationally representative data. Weighted univariate and multivariate logistic regression analysis was used to assess the association of participant’s characteristics and use of tobacco. Results: Of 6039 targeted respondents, 5664 (93.8%) participated, - 2707 males, 2929 females, and 28 missing with gender. From the unadjusted analysis, age (p=0.001), pocket money (p Journal of Preventive Medicine and Hygiene, Vol. 62 No. 3 (2021): 2021623
