Immune reconstitution following hematopoietic stem cell transplantation using different stem cell sources
| العنوان: | Immune reconstitution following hematopoietic stem cell transplantation using different stem cell sources |
|---|---|
| المؤلفون: | Paul Veys, Waseem Qasim, Reem Elfeky, Arina Lazareva |
| المصدر: | Expert Review of Clinical Immunology. 15:735-751 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Receptors, Antigen, T-Cell, alpha-beta, Lymphocyte, medicine.medical_treatment, Antigens, CD19, Immunology, chemical and pharmacologic phenomena, Hematopoietic stem cell transplantation, CD19, Immune system, medicine, Animals, Humans, Immunology and Allergy, biology, business.industry, Hematopoietic Stem Cell Transplantation, Recovery of Function, Allografts, Hematopoietic Stem Cells, Transplantation, medicine.anatomical_structure, Cord blood, biology.protein, Bone marrow, Stem cell, business |
| الوصف: | Introduction: Adequate immune reconstitution post-HSCT is crucial for the success of transplantation, and can be affected by both patient- and transplant-related factors. Areas covered: A systematic literature search in PubMed, Scopus, and abstracts of international congresses is performed to investigate immune recovery posttransplant. In this review, we discuss the pattern of immune recovery in the post-transplant period focusing on the impact of stem cell source (bone marrow, peripheral blood stem cells, and cord blood) on immune recovery and HSCT outcome. We examine the impact of serotherapy on immune reconstitution and the need to tailor dosing of serotherapy agents when using different stem cell sources. We discuss new techniques being used particularly with cord blood and haploidentical grafts to improve immune recovery in each scenario. Expert opinion: Cord blood T cells provide a unique CD4+ biased immune reconstitution. Initial studies using targeted serotherapy with cord grafts showed improved immune recovery with limited alloreactivity. Two competing haploidentical approaches have developed in recent years including TCRαβ/CD19 depleted grafts and post-cyclophosphamide haplo-HSCT. Both approaches have comparable survival rates with limited alloreactivity. However, delayed immune reconstitution is still an ongoing problem and could be improved by modified donor lymphocyte infusions from the same haploidentical donor. |
| تدمد: | 1744-8409 1744-666X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093fb1a63a0755d91a0135e7364ddea8 https://doi.org/10.1080/1744666x.2019.1612746 |
| رقم الأكسشن: | edsair.doi.dedup.....093fb1a63a0755d91a0135e7364ddea8 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17448409 1744666X |
|---|