Palladium-Catalyzed Synthesis of Tricyclic Indoles via a N–S Bond Cleavage Strategy
| العنوان: | Palladium-Catalyzed Synthesis of Tricyclic Indoles via a N–S Bond Cleavage Strategy |
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| المؤلفون: | Yuke Li, Zheng-Jun Quan, Xue-Ya Gou, Bo-Sheng Zhang, Fan Wang, Xicun Wang, Yong-Min Liang, Ying-Hui Yang, Wan-Yuan Jia |
| المصدر: | Organic Letters. 23:7518-7523 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Indole test, Organic Chemistry, chemistry.chemical_element, Biochemistry, Medicinal chemistry, Coupling reaction, Catalysis, chemistry.chemical_compound, chemistry, Reaction system, Physical and Theoretical Chemistry, Bond cleavage, Norbornene, Tricyclic, Palladium |
| الوصف: | In palladium/norbornene (Pd/NBE) chemistry, the "ortho effect" has been proven to be a key factor in the process of β-carbon elimination to extrude NBE. Herein, we found that the o-iodoaniline protected by a p-methoxybenzenesulfonyl group can recover the "ortho effect" and then undergo N-S bond cleavage with vinyl palladium, thus achieving a highly selective C-N coupling reaction in the Catallani-Lautens reaction system. On the basis of this discovery, a one-step synthesis of highly functionalized tricyclic indole derivatives was realized. |
| تدمد: | 1523-7052 1523-7060 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0985b1ff25785e5efcf711b9534ef5ff https://doi.org/10.1021/acs.orglett.1c02715 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0985b1ff25785e5efcf711b9534ef5ff |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15237052 15237060 |
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