The Effect of TNF-alpha rs1800629 Polymorphism on White Matter Structures and Memory Function in Patients With Schizophrenia: A Pilot Study
| العنوان: | The Effect of TNF-alpha rs1800629 Polymorphism on White Matter Structures and Memory Function in Patients With Schizophrenia: A Pilot Study |
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| المؤلفون: | Naok Kang, Wonsuk Shin, Sra Jung, Minji Bang, Sang-Hyuk Lee |
| المصدر: | Psychiatry Investigation. 19:1027-1036 |
| بيانات النشر: | Korean Neuropsychiatric Association, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Psychiatry and Mental health, Biological Psychiatry |
| الوصف: | Objective This study investigated the effect of TNF-α rs1800629 polymorphism on white matter integrity and memory function in patients with schizophrenia.Methods Fifty-five participants with schizophrenia were enrolled in this study. They were genotyped for TNF-α rs1800629 polymorphism and underwent diffusion tensor imaging. Memory function was assessed using the Rey–Kim memory test. Participants with schizophrenia were grouped into GG homozygotes and A-allele carriers.Results Compared to GG homozygotes, A-allele carriers had significantly lower scores for immediate and delayed recall and recognition of verbal memory and showed significantly lower fractional anisotropy in extensive brain regions. Lower total scores in immediate and delayed recall of verbal memory, immediate recall of visual memory, and figure copy of visual memory were significantly correlated with decreased mean fractional anisotropy in the white matter tracts of the corresponding brain regions.Conclusion Our findings suggest that the A-allele, which is associated with higher levels of TNF-α expression, correlates with lower connectivity of the fronto-temporal white matter compared to that in GG homozygotes. Impaired fronto-temporal connectivity may be associated with genetic vulnerability to schizophrenia, leading to verbal and visual memory deficits in patients with schizophrenia. |
| تدمد: | 1976-3026 1738-3684 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a34ac1d032018dd48b5d67f75fdc60a https://doi.org/10.30773/pi.2021.0326 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0a34ac1d032018dd48b5d67f75fdc60a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19763026 17383684 |
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