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In vivo human retinal swept source optical coherence tomography and angiography at 830 nm with a CMOS compatible photonic integrated circuit

التفاصيل البيبلوغرافية
العنوان: In vivo human retinal swept source optical coherence tomography and angiography at 830 nm with a CMOS compatible photonic integrated circuit
المؤلفون: Paul Muellner, Stefan Nevlacsil, Wolfgang Drexler, Rainer Hainberger, Stefan Gloor, Rainer A. Leitgeb, Elisabet Rank, Jochen Kraft, Martin Sagmeister, Marcus Duelk, Matthias Salas
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
بيانات النشر: Springer Science and Business Media LLC, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Science, Silicon photonics, 02 engineering and technology, 01 natural sciences, Article, Retina, law.invention, 010309 optics, Optics, Optical coherence tomography, law, 0103 physical sciences, medicine, Humans, Sensitivity (control systems), Physics, Multidisciplinary, medicine.diagnostic_test, business.industry, Photonic integrated circuit, Angiography, Center (category theory), Integrated optics, Equipment Design, 021001 nanoscience & nanotechnology, Wavelength, Interferometry, Splitter, Three-dimensional imaging, Medicine, 0210 nano-technology, business, Tomography, Optical Coherence, Beam splitter
الوصف: Photonic integrated circuits (PIC) provide promising functionalities to significantly reduce the size and costs of optical coherence tomography (OCT) systems. This paper presents an imaging platform operating at a center wavelength of 830 nm for ophthalmic application using PIC-based swept source OCT. An on-chip Mach–Zehnder interferometer (MZI) configuration, which comprises an input power splitter, polarization beam splitters in the sample and the reference arm, and a 50/50 coupler for signal interference represents the core element of the system with a footprint of only $$(12 \times 5)\;{\text {mm}}^2$$ ( 12 × 5 ) mm 2 . The system achieves 94 dB imaging sensitivity with 750 $$\upmu $$ μ W on the sample, 50 kHz imaging speed and 5.5 $$\upmu $$ μ m axial resolution (in soft tissue). With this setup, in vivo human retinal imaging of healthy subjects was performed producing B-scans, three-dimensional renderings as well as OCT angiography. These promising results are significant prerequisites for further integration of optical and electronic building blocks on a single swept source-OCT PIC.
تدمد: 2045-2322
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a66770964ef816ebc3c0bea25c2181d
https://doi.org/10.1038/s41598-021-00637-4
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....0a66770964ef816ebc3c0bea25c2181d
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20452322