The effect of β‐amyloid positivity on cerebral metabolism in cognitively normal seniors
| العنوان: | The effect of β‐amyloid positivity on cerebral metabolism in cognitively normal seniors |
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| المؤلفون: | Monica Zdanukiewicz, Andrea Bozoki, David C. Zhu |
| المصدر: | Alzheimer's & Dementia. 12:1250-1258 |
| بيانات النشر: | Wiley, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Apolipoprotein E, Aging, Amyloid, Pathology, medicine.medical_specialty, Epidemiology, Apolipoprotein E4, Hippocampus, Standardized uptake value, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Neuroimaging, Fluorodeoxyglucose F18, medicine, Humans, Aged, Cerebral Cortex, medicine.diagnostic_test, Health Policy, Entorhinal cortex, Psychiatry and Mental health, Glucose, 030104 developmental biology, medicine.anatomical_structure, Positron emission tomography, Cerebral cortex, Positron-Emission Tomography, Posterior cingulate, Female, Neurology (clinical), Radiopharmaceuticals, Geriatrics and Gerontology, Psychology, 030217 neurology & neurosurgery |
| الوصف: | Introduction We evaluated the effect of cerebral amyloid-β (Aβ) deposition in cognitively normal (CN) seniors on regional metabolism of specific brain regions known to be affected by p-tau deposition. Methods Fluorodeoxyglucose positron emission tomography (FDG-PET), volumetric magnetic resonance imaging scans, and global amyloid standardized uptake value ratios (SUVr) were obtained for 210 CNs from the Alzheimer's Disease Neuroimaging Initiative-2 ( ADNI2 ). Region of interest (ROI) extraction was used to obtain functional SUVr from six bilateral ROIs: amygdala (AM), entorhinal cortex (EC), hippocampus, lateral orbitofrontal, posterior cingulate (PC), and middle temporal gyrus. Every metabolic SUVr set was averaged and analyzed against the corresponding subject's amyloid SUVr. Correlation analyses were conducted on the full group and between APOE e4-positive and APOE e4-negative subgroups. Results The APOE e4+ group exhibited significantly higher metabolism in the EC (r = 0.270, P = .038) and AM (r = 0.267, P = .041). When a significance of the difference test was conducted between the APOE e4+ and APOE e4-groups, these same regions remained significant: P = .012 and P = .016, respectively. By contrast, the APOE e4 group displayed only the conventionally expected result of reduced regional metabolism in the PC (r = −0.161, P = .048), with higher Aβ load. Conclusions The effect of amyloid positivity on brain metabolism is regionally specific, and APOE e4 status substantially modulates regional glucose uptake in these regions. The APOE e4 allele may cause earlier emergence of clinical symptoms in AD via a mechanism that influences regional metabolic demand in specifically those regions where p-tau deposition is known to occur earliest. |
| تدمد: | 1552-5279 1552-5260 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a71938dff2a64e8f28aabc9f66f647e https://doi.org/10.1016/j.jalz.2016.06.003 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0a71938dff2a64e8f28aabc9f66f647e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525279 15525260 |
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