IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells
| العنوان: | IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells |
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| المؤلفون: | Akram Obeidat, Rachel Yamin, Einat Seidel, Merav Hecht, Pinchas Tsukerman, Moriya Gamliel, Ofer Mandelboim, Adi Reches, Alexandra Duev-Cohen, Yoav Charpak-Amikam, Dominik Schmiedel, Orit Berhani, Inbal Kol, Natan Stein |
| المصدر: | iScience, Vol 11, Iss, Pp 466-473 (2019) iScience |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Multidisciplinary, Interferon-gamma production, NK cell activation, Immunology, 02 engineering and technology, Disease, Biology, 021001 nanoscience & nanotechnology, Article, Cell biology, 03 medical and health sciences, 030104 developmental biology, Immune system, Molecular Mechanism of Gene Regulation, medicine, Secretion, Interferon gamma, lcsh:Q, 0210 nano-technology, lcsh:Science, Molecular Biology, Immune Response, Function (biology), medicine.drug |
| الوصف: | Summary Long, non-coding RNAs (lncRNAs) are involved in the regulation of many cellular processes. The lncRNA IFNG-AS1 was found to strongly influence the responses to several pathogens in mice by increasing interferon gamma (IFNγ) secretion. Studies have looked at IFNG-AS1 in T cells, yet IFNG-AS1 function in natural killer cells (NKs), an important source of IFNγ, remains unknown. Here, we show a previously undescribed sequence of IFNG-AS1 and report that it may be more abundant in cells than previously thought. Using primary human NKs and an NK line with IFNG-AS1 overexpression, we show that IFNG-AS1 is quickly induced upon NK cell activation, and that IFNG-AS1 overexpression leads to increased IFNγ secretion. Taken together, our work expands IFNG-AS1's activity to the innate arm of the type I immune response, helping to explain its notable effect in animal models of disease. Graphical Abstract Highlights • Natural killer cells (NKs) express a previously undescribed transcript of IFNG-AS1 • Upon activation, NKs upregulate IFNG-AS1 along with later IFNγ expression • Overexpression of IFNG-AS1 in an NK line augments IFNγ expression and secretion • IFNG-AS1 influences innate immunity, suggesting a general role in the IFNγ response Molecular Biology; Molecular Mechanism of Gene Regulation; Immunology; Immune Response |
| اللغة: | English |
| تدمد: | 2589-0042 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab8c7388236ea9ba9bff8ca06c38818 http://www.sciencedirect.com/science/article/pii/S2589004218302645 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0ab8c7388236ea9ba9bff8ca06c38818 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25890042 |
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