Beneficial effects of baicalein on a model of allergic rhinitis
| العنوان: | Beneficial effects of baicalein on a model of allergic rhinitis |
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| المؤلفون: | Shaohua Wang, Dengdian Ma, Wenzhong Wei, Jing Yao, Mengwei Yao, Detao Ding, Yungang Wu, Wei Zhang, Xiaoyu Li, Xiaoxia Li, Tao Liu, Jing Xu |
| المصدر: | Acta Pharmaceutica Volume 70 Issue 1 Acta Pharmaceutica, Vol 70, Iss 1, Pp 35-47 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, baicalein, Ovalbumin, Lymphocyte, Pharmaceutical Science, Inflammation, Mucous membrane of nose, Pharmacology, Proinflammatory cytokine, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, inflammatory factors, ovalbumin, allergic rhinitis, p-STAT3, In vivo, medicine, Animals, Lymphocytes, Pharmaceutical industry, 030304 developmental biology, 0303 health sciences, biology, business.industry, General Medicine, respiratory system, medicine.disease, Rhinitis, Allergic, Baicalein, Rats, Eosinophils, Disease Models, Animal, Nasal Mucosa, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Flavanones, biology.protein, p-stat3, medicine.symptom, HD9665-9675, business, Anaphylaxis |
| الوصف: | Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology. |
| وصف الملف: | application/pdf |
| تدمد: | 1846-9558 1330-0075 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acfa3b0594c25978f2fa31e7b58a9ec https://pubmed.ncbi.nlm.nih.gov/31677374 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0acfa3b0594c25978f2fa31e7b58a9ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18469558 13300075 |
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