Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant
| العنوان: | Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant |
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| المؤلفون: | Wil A. Allebes, F. J. van Ittersum, Henny G. Otten, Wendy Swelsen, P.J.M. van der Boog, E.M. van Duijnhoven, Michiel G. H. Betjes, Loes Plaisier, Jan-Stephan F. Sanders, Elena G. Kamburova, Maarten H. L. Christiaans, Bouke G. Hepkema, Cornelis E. Hack, Marc A. Seelen, Christina E.M. Voorter, Marcel G.J. Tilanus, I. J. M. ten Berge, A D van Zuilen, Adriaan C.A.D. Drop, Sebastiaan Heidt, Caroline Roozendaal, N M Lardy, Laura Bungener, Dave L. Roelen, Marije C. Baas, Lotte Wieten, K. A. M. I. van Donselaar-van der Pant, Shaikh A. Nurmohamed, Michiel L. Bots, M. Gelens, F. van Reekum, Bram W. Wisse, Frederike J. Bemelman, N. C. van der Weerd, Annechien J. A. Lambeck, Luuk B. Hilbrands, A. F. G. van der Meer, Irma Joosten, Marianne C. Verhaar, A. J. Hoitsma, Frans H.J. Claas, J.W. de Fijter, Eric Spierings |
| المساهمون: | Internal Medicine, Nephrology, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, AII - Inflammatory diseases, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Interne Geneeskunde, MUMC+: DA Transplantatie Immunologie (5), MUMC+: DA TI Staf (9), MUMC+: DA TI Laboratorium (9), MUMC+: MA Nefrologie (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, AII - Amsterdam institute for Infection and Immunity, APH - Aging & Later Life |
| المصدر: | American Journal of Transplantation, 18, 9, pp. 2274-2284 American Journal of Transplantation, 18, 2274-2284 American Journal of Transplantation Kamburova, E G, Wisse, B W, Joosten, I, Allebes, W A, van der Meer, A, Hilbrands, L B, Baas, M C, Spierings, E, Hack, C E, van Reekum, F E, van Zuilen, A D, Verhaar, M C, Bots, M L, Drop, A C A D, Plaisier, L, Seelen, M A J, Sanders, J S F, Hepkema, B G, Lambeck, A J A, Bungener, L B, Roozendaal, C, Tilanus, M G J, Voorter, C E, Wieten, L, van Duijnhoven, E M, Gelens, M, Christiaans, M H L, van Ittersum, F J, Nurmohamed, S A, Lardy, N M, Swelsen, W, van der Pant, K A, van der Weerd, N C, ten Berge, I J M, Bemelman, F J, Hoitsma, A, van der Boog, P J M, de Fijter, J W, Betjes, M G H, Heidt, S, Roelen, D L, Claas, F H & Otten, H G 2018, ' Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant ', American Journal of Transplantation, vol. 18, no. 9, pp. 2274-2284 . https://doi.org/10.1111/ajt.14709 American Journal of Transplantation, 18(9), 2274-2284. Wiley-Blackwell Publishing Ltd American Journal of Transplantation, 18(9), 2274-2284. Wiley-Blackwell American Journal of Transplantation, 18(9), 2274-2284. Wiley American Journal of Transplantation, 18(9), 2274. Blackwell Publishing Asia Pty Ltd American Journal of Transplantation, 18(9), 2274-2284 American journal of transplantation, 18(9), 2274-2284. Wiley-Blackwell |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Graft Rejection, Male, Nephrology, graft survival, 030232 urology & nephrology, kidney transplantation/nephrology, 030230 surgery, Single Center, CROSS-MATCH, Gastroenterology, Kidney transplantation, Postoperative Complications, 0302 clinical medicine, LONG-TERM OUTCOMES, HLA Antigens, Isoantibodies, Risk Factors, Living Donors, Immunology and Allergy, HIGHLY SENSITIZED PATIENTS, Pharmacology (medical), RISK, Kidney transplantation/nephrology, Alloantibody, biology, Living donor, RENAL-TRANSPLANTATION, Graft survival, GRAFT LOSS, Middle Aged, Clinical Science, Prognosis, practice, Survival Rate, kidney failure/injury, surgical procedures, operative, REJECTION, Clinical research/practice, Female, Original Article, Antibody, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], Adult, medicine.medical_specialty, KIDNEY-TRANSPLANTATION, injury, nephrology, kidney transplantation, living donor, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], Human leukocyte antigen, clinical research/practice, Donor Selection, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Antigen, Internal medicine, Journal Article, Cadaver, alloantibody, medicine, Humans, Risk factor, Retrospective Studies, Transplantation, business.industry, HUMAN-LEUKOCYTE ANTIGEN, medicine.disease, kidney failure, body regions, Kidney failure/injury, clinical research, biology.protein, Kidney Failure, Chronic, ORIGINAL ARTICLES, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business, SINGLE-CENTER, Follow-Up Studies |
| الوصف: | The presence of donor‐specific anti‐HLA antibodies (DSAs) is associated with increased risk of graft failure after kidney transplant. We hypothesized that DSAs against HLA class I, class II, or both classes indicate a different risk for graft loss between deceased and living donor transplant. In this study, we investigated the impact of pretransplant DSAs, by using single antigen bead assays, on long‐term graft survival in 3237 deceased and 1487 living donor kidney transplants with a negative complement‐dependent crossmatch. In living donor transplants, we found a limited effect on graft survival of DSAs against class I or II antigens after transplant. Class I and II DSAs combined resulted in decreased 10‐year graft survival (84% to 75%). In contrast, after deceased donor transplant, patients with class I or class II DSAs had a 10‐year graft survival of 59% and 60%, respectively, both significantly lower than the survival for patients without DSAs (76%). The combination of class I and II DSAs resulted in a 10‐year survival of 54% in deceased donor transplants. In conclusion, class I and II DSAs are a clear risk factor for graft loss in deceased donor transplants, while in living donor transplants, class I and II DSAs seem to be associated with an increased risk for graft failure, but this could not be assessed due to their low prevalence. Via a retrospective multicenter study, the authors investigate the impact of pretransplant donor‐specific HLA antibodies on long‐term graft survival in deceased and living donor kidney transplantations. |
| وصف الملف: | application/pdf; image/pdf |
| تدمد: | 1600-6135 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae22784d5d9a941d4106b4cf62b4d0f https://hdl.handle.net/2066/195255 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0ae22784d5d9a941d4106b4cf62b4d0f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16006135 |
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