Patients with FGF23-related hypophosphatemic rickets/osteomalacia do not present with left ventricular hypertrophy
| العنوان: | Patients with FGF23-related hypophosphatemic rickets/osteomalacia do not present with left ventricular hypertrophy |
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| المؤلفون: | Yuka Kinoshita, Manabu Taguchi, Michiko Hori, Seiji Fukumoto, Nobuaki Ito, Yuichi Takashi |
| المصدر: | Endocrine Research. 42:132-137 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Fibroblast growth factor 23, medicine.medical_specialty, urologic and male genital diseases, Left ventricular hypertrophy, Young Adult, 03 medical and health sciences, Endocrinology, Internal medicine, Humans, Medicine, In patient, cardiovascular diseases, Aged, Osteomalacia, business.industry, General Medicine, Middle Aged, medicine.disease, Rickets, Hypophosphatemic, Fibroblast Growth Factors, Fibroblast Growth Factor-23, stomatognathic diseases, Hypophosphatemic Rickets, 030104 developmental biology, Cardiac hypertrophy, Female, Hypertrophy, Left Ventricular, business, Hormone, Kidney disease |
| الوصف: | Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate metabolism. Excessive actions of FGF23 cause several types of FGF23-related hypophosphatemic rickets/osteomalacia. Recently, it was reported that FGF23 levels were independently correlated with left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD). In addition, FGF23 was also shown to cause cardiac hypertrophy directly acting on cardiomyocytes. However, there is no study indicating the correlation between FGF23 and LVH in adult patients with FGF23-related hypophosphatemic rickets/osteomalacia. Therefore, we examined the existence of LVH in these patients.We recruited consecutive 24 patients with FGF23-related hypophosphatemic diseases. Their serum intact FGF23 levels and the parameters associated with LVH, including left ventricular mass index (LVMI), relative wall thickness (RWT), Sokolow-Lyon voltage, and Cornell product, were measured. The correlations between FGF23 and these parameters were examined.The participants did not show LVH on the whole. In addition, no significant correlation was observed by these examinations.It seems unlikely that FGF23 levels are the apparent determinant of the cardiac mass in patients with FGF23-related hypophosphatemic rickets/osteomalacia. |
| تدمد: | 1532-4206 0743-5800 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b085913b3be633ecca5ae3aea01615d https://doi.org/10.1080/07435800.2016.1242604 |
| رقم الأكسشن: | edsair.doi.dedup.....0b085913b3be633ecca5ae3aea01615d |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15324206 07435800 |
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