Lack of association between circulating apelin level and frailty-related functional parameters in older adults: a cross-sectional study
| العنوان: | Lack of association between circulating apelin level and frailty-related functional parameters in older adults: a cross-sectional study |
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| المؤلفون: | Da Ae Kim, Beom-Jun Kim, Il-Young Jang, So Jeong Park, Mark W. Hamrick, Seungjoo Lee, Eunju Lee, Jeoung Hee Kim, Jin Young Lee, Jin Hoon Park |
| المصدر: | BMC Geriatrics, Vol 20, Iss 1, Pp 1-9 (2020) BMC Geriatrics |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Aging, Sarcopenia, Cross-sectional study, Frail Elderly, lcsh:Geriatrics, 03 medical and health sciences, Grip strength, Mice, 0302 clinical medicine, Internal medicine, medicine, Animals, Humans, 030212 general & internal medicine, Geriatric Assessment, Aged, Frailty, business.industry, Biomarker, medicine.disease, Apelin, lcsh:RC952-954.6, Cross-Sectional Studies, Quartile, Cohort, Biomarker (medicine), Geriatrics and Gerontology, business, Body mass index, 030217 neurology & neurosurgery, Research Article |
| الوصف: | Background Apelin, an active endogenous peptide, has been recently receiving great attention as a promising target for antiaging intervention, primarily based on results from genetically altered mice. To validate previous experimental data and investigate the possible role of apelin in humans, in this study, we examined serum apelin level in relation to frailty and its associated parameters in a cohort of ambulatory, community-dwelling older adults. Methods Blood samples were collected from 80 participants who underwent a comprehensive geriatric assessment, and apelin level was measured using an enzyme immunoassay kit. Phenotypic frailty and deficit-accumulation frailty index (FI) were assessed using widely validated approaches, proposed by Fried and Rockwood groups, respectively. Results After adjustment for sex, age, and body mass index, serum apelin level was found to be not significantly different according to phenotypic frailty status (P = 0.550) and not associated with FI, grip strength, gait speed, time to complete 5 chair stands, and muscle mass (P = 0.433 to 0.982). To determine whether the association between serum apelin level and frailty has a threshold effect, we divided the participants into quartiles according to serum apelin level. However, there were no differences in terms of frailty-related parameters and the risk for frailty among the quartile groups (P = 0.248 to 0.741). Conclusions The serum apelin level was not associated with both phenotypic frailty and functional parameters in older adults, despite its beneficial effects against age-related physiologic decline in animal models. Further large-scale longitudinal studies are necessary to understand the definite role of circulating apelin in frailty risk assessment. |
| اللغة: | English |
| تدمد: | 1471-2318 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3e7617cfa9a2e349ec9a6521fd74f3 http://link.springer.com/article/10.1186/s12877-020-01837-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0b3e7617cfa9a2e349ec9a6521fd74f3 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712318 |
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