Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe
| العنوان: | Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe |
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| المؤلفون: | M. Guix, Ramon Clèries, M. Torres, S. Marquez, Jon Frias-Gomez, B Lloveras, Sara Tous, Ricard Mesia, Jacinto García, Antoni Baena, Miquel Angel Pavon, Rafael Hijano, Laia Alemany, Marisa Mena, Maria Alejo, T. Bonfill, Xavier León, O Clavero, Antón Aguilà, Miren Taberna, O Bermejo, B. Quirós |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Scientific Reports r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Papillomaviruses, Epidemiology, lcsh:Medicine, Disease, Alphapapillomavirus, Article, Cohort Studies, Cancer epidemiology, Internal medicine, Prevalence, Humans, Medicine, Tumour virus infections, lcsh:Science, Head and neck cancer, Papil·lomavirus, Epidemiologia, Aged, Retrospective Studies, Aged, 80 and over, Multidisciplinary, business.industry, Incidence (epidemiology), Medical record, lcsh:R, Papillomavirus Infections, virus diseases, Cancer, Retrospective cohort study, Middle Aged, Neck cancer, medicine.disease, Càncer de coll, Faringe--Càncer--Europa, Europe, Oropharyngeal Neoplasms, medicine.anatomical_structure, Tonsil, lcsh:Q, Female, business, Cohort study |
| الوصف: | The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16INK4a double positivity being considered. HPV-related oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012–2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting, as occurred two decades ago in areas where most oropharyngeal cancer cases are currently HPV-related. Our results provide a comprehensive assessment of the epidemiological landscape of HPV-related oropharyngeal cancer in a region of southern Europe. |
| وصف الملف: | application/pdf |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b477dba65846c6e84f4b3bae22bff6f https://doi.org/10.1038/s41598-020-70118-7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0b477dba65846c6e84f4b3bae22bff6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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