White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
| العنوان: | White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer |
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| المؤلفون: | Donald L. van der Peet, Marcel Verheij, Jamie E. Medina, Mark A. M. Broeckaert, Jenna Van Liere Canzoniero, Fabiënne A. R. M. Warmerdam, Daniel C. Bruhm, Dick Johan van Spronsen, Valsamo Anagnostou, Johanneke E.A. Portielje, Robert B. Scharpf, Maud M. Geenen, Marianne Nordsmark, Gerrit A. Meijer, Henk M.W. Verheul, Doreen N. Palsgrove, Jacob Fiksel, Remond J.A. Fijneman, Johanna W. van Sandick, Victor E. Velculescu, Carolyn Hruban, Annemieke Cats, Cornelis J.H. van de Velde, Elma Meershoek – Klein Kranenbarg, Laurens V. Beerepoot, Hanneke W. M. van Laarhoven, Edwin P.M. Jansen, Alessandro Leal, Jillian Phallen, Vilmos Adleff, Nicole C.T. van Grieken |
| المساهمون: | Pathology, CCA - Imaging and biomarkers, Amsterdam Gastroenterology Endocrinology Metabolism, Internal medicine, Medical oncology, Surgery, Oncology, AGEM - Re-generation and cancer of the digestive system |
| المصدر: | Nature Communications, 11(1):525. Nature Publishing Group UK Nature Communications, 11 Nature Communications, 11(1). NATURE PUBLISHING GROUP Nature Communications, 11, 1 Leal, A, van Grieken, N C T, Palsgrove, D N, Phallen, J, Medina, J E, Hruban, C, Broeckaert, M A M, Anagnostou, V, Adleff, V, Bruhm, D C, Canzoniero, J V, Fiksel, J, Nordsmark, M, Warmerdam, F A R M, Verheul, H M W, van Spronsen, D J, Beerepoot, L V, Geenen, M M, Portielje, J E A, Jansen, E P M, van Sandick, J, Meershoek-Klein Kranenbarg, E, van Laarhoven, H W M, van der Peet, D L, van de Velde, C J H, Verheij, M, Fijneman, R, Scharpf, R B, Meijer, G A, Cats, A & Velculescu, V E 2020, ' White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer ', Nature Communications, vol. 11, no. 1, 525 . https://doi.org/10.1038/s41467-020-14310-3 Nature Communications Nature communications, 11(1):525. Nature Publishing Group Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, SURGERY, General Physics and Astronomy, Disease, law.invention, Prognostic markers, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Randomized controlled trial, law, Leukocytes, lcsh:Science, Randomized Controlled Trials as Topic, Multidisciplinary, PLASMA, CLONAL HEMATOPOIESIS, DNA, Neoplasm, CHEMOTHERAPY, Prognosis, 3. Good health, Haematopoiesis, medicine.anatomical_structure, Cell-free fetal DNA, 030220 oncology & carcinogenesis, SURVIVAL, Cell-Free Nucleic Acids, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], medicine.medical_specialty, CARCINOMA, Science, Proof of Concept Study, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, LUNG-CANCER, All institutes and research themes of the Radboud University Medical Center, Stomach Neoplasms, Internal medicine, White blood cell, REGRESSION, medicine, Humans, Survival analysis, business.industry, CIRCULATING TUMOR DNA, Cancer, Sequence Analysis, DNA, General Chemistry, Perioperative, medicine.disease, Survival Analysis, Hematopoiesis, 030104 developmental biology, lcsh:Q, Neoplasm Recurrence, Local, Gastric cancer, business, ACQUIRED-RESISTANCE |
| الوصف: | Liquid biopsies are providing new opportunities for detection of residual disease in cell-free DNA (cfDNA) after surgery but may be confounded through identification of alterations arising from clonal hematopoiesis. Here, we identify circulating tumor-derived DNA (ctDNA) alterations through ultrasensitive targeted sequencing analyses of matched cfDNA and white blood cells from the same patient. We apply this approach to analyze samples from patients in the CRITICS trial, a phase III randomized controlled study of perioperative treatment in patients with operable gastric cancer. After filtering alterations from matched white blood cells, the presence of ctDNA predicts recurrence when analyzed within nine weeks after preoperative treatment and after surgery in patients eligible for multimodal treatment. These analyses provide a facile method for distinguishing ctDNA from other cfDNA alterations and highlight the utility of ctDNA as a predictive biomarker of patient outcome to perioperative cancer therapy and surgical resection in patients with gastric cancer. Identifying patients that will respond to a particular therapy remains a key challenge in precision oncology. Here, in gastric cancer, the authors show that circulating tumour DNA can predict recurrence, provided that the signal from white blood cells is filtered out. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b47eb72ae34b19261aae2b68d7be87a https://doi.org/10.1038/s41467-020-14310-3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0b47eb72ae34b19261aae2b68d7be87a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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