The Effects of Inactive Platelet-rich Plasma at Different Injection Time on Prefabricated Flap Viability in Rabbits
| العنوان: | The Effects of Inactive Platelet-rich Plasma at Different Injection Time on Prefabricated Flap Viability in Rabbits |
|---|---|
| المؤلفون: | Zhiguo Su, Hongbo Chen, Yan Zeng, Tiran Zhang, Hua Zhang, Jincai Fan |
| المصدر: | Annals of Plastic Surgery. 86:701-706 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, medicine.medical_treatment, 030230 surgery, Revascularization, Surgical Flaps, Injections, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.artery, medicine, Animals, Survival rate, Saline, Thoracodorsal artery, medicine.diagnostic_test, Platelet-Rich Plasma, business.industry, Graft Survival, Skin Transplantation, Vascular bundle, Surgery, Vascular endothelial growth factor, chemistry, 030220 oncology & carcinogenesis, Platelet-rich plasma, Angiography, Rabbits, business |
| الوصف: | Purpose To evaluate the effect of inactive form of platelet-rich plasma (PRP) at different injection time on the prefabricated flap viability in rabbits. Methods A thoracodorsal artery vascular bundle prefabricated flap was established on the back of 30 healthy male New Zealand white rabbits by 2 phases of operations. A total of 60 sides were randomly divided into the experimental side and the control side. The experimental side was injected with autologous inactive PRP around the thoracodorsal vascular bundle, and the control side was injected with the same amount of normal saline. According to preoperative (group A), intraoperative (group B), and postoperative (group C) injection of PRP, 30 rabbits were divided into 3 groups of 10 each. Histological and immunohistochemical observation, vascular density measurement, and lead oxide angiography were used to compare the differences in the survival of prefabricated flaps between the 3 groups of rabbits injected with inactive PRP at different injection time. Results The flap survival ratio, microvessels density, vascular endothelial growth factor and vascular endothelial growth factor receptor 2 expression of PRP injection side were significantly improved compared with the control side. In the comparison of 3 injection time groups, we found that group A and group B could achieve better results, and especially group B had the most significant effect on the revascularization and flap viability. Conclusion Autologous inactive PRP can promote the survival of the prefabricated flap, and the intraoperative injection can significantly improve the survival rate of the prefabricated flap. It provides a theoretical guidance for obtaining a larger area of prefabricated axial flap in clinical practice. |
| تدمد: | 1536-3708 0148-7043 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6e3c5d4252420f727d16b03da61453 https://doi.org/10.1097/sap.0000000000002541 |
| رقم الأكسشن: | edsair.doi.dedup.....0b6e3c5d4252420f727d16b03da61453 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15363708 01487043 |
|---|