Antiremodeling agents influence osteoblast activity differently in modeling and remodeling sites of canine rib
| العنوان: | Antiremodeling agents influence osteoblast activity differently in modeling and remodeling sites of canine rib |
|---|---|
| المؤلفون: | M. Khurana, David B. Burr, Masahiko Sato, Matthew R. Allen, Hélène Follet |
| المساهمون: | Follet, Helene, University of Oxford, Columbia University Earth Institute, Columbia University [New York], Ostéoporose et Qualité Osseuse, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-IFR62-Institut National de la Santé et de la Recherche Médicale (INSERM), Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, University of Oxford [Oxford] |
| المصدر: | Calcified Tissue International Calcified Tissue International, 2006, 79 (4), pp.255-61. ⟨10.1007/s00223-006-0031-5⟩ Calcified Tissue International, Springer Verlag, 2006, 79 (4), pp.255-61. ⟨10.1007/s00223-006-0031-5⟩ |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | MESH: Etidronic Acid, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, MESH: Bone Matrix, Bone Matrix, MESH: Dogs, 0302 clinical medicine, Endocrinology, MESH: Animals, Orthopedics and Sports Medicine, MESH: Alendronate, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, 0303 health sciences, Alendronate, Bone Density Conservation Agents, Chemistry, Osteoblast, Etidronic Acid, MESH: Ribs, medicine.anatomical_structure, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Selective estrogen receptor modulator, Female, Bone Remodeling, Risedronic Acid, medicine.drug, medicine.medical_specialty, 030209 endocrinology & metabolism, Ribs, MESH: Bone Density Conservation Agents, 03 medical and health sciences, Dogs, MESH: Bone Remodeling, Internal medicine, Periosteum, medicine, MESH: Periosteum, Animals, Raloxifene, Bone formation, 030304 developmental biology, MESH: Raloxifene, MESH: Osteoblasts, Osteoblasts, Bisphosphonate, Differential effects, Apposition, Raloxifene Hydrochloride, MESH: Female |
| الوصف: | The first two authors (Allen M. and Follet H.) contributed equally to this work; International audience; Antiremodeling agents reduce bone loss in part through direct actions on osteoclasts. Their effects on osteoblasts and bone formation activity are less clear and may differ at sites undergoing modeling vs. remodeling. Skeletally mature intact beagles, 1-2 years old at the start of the study, were treated daily with clinically relevant doses of alendronate (0.10 or 0.20 mg/kg), risedronate (0.05 or 0.10 mg/kg), raloxifene (0.50 mg/kg), or vehicle (1 mL/kg). Dynamic bone formation parameters were histologically assessed on periosteal, endocortical/trabecular, and intracortical bone envelopes of the rib. Raloxifene significantly increased periosteal surface mineral apposition rate (MAR), a measure of osteoblast activity, compared to all other treatments (+108 to +175%, P < 0.02), while having no significant effect on MAR at either the endocortical/trabecular or intracortical envelope. Alendronate (both 0.10 and 0.20 doses) and risedronate (only the 0.10 dose) significantly (P < or = 0.05) suppressed MAR on the endocortical/trabecular envelope, while none of the bisphosphonate doses significantly altered MAR at either the periosteal or intracortical envelopes compared to vehicle. Based on these results, we conclude that (1) at clinically relevant doses the two classes of antiremodeling agents, bisphosphonates and selective estrogen receptor modulators, exert differential effects on osteoblast activity in the canine rib and (2) this effect depends on whether modeling or remodeling is the predominant mechanism of bone formation. |
| وصف الملف: | application/pdf |
| تدمد: | 0171-967X 1432-0827 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9dcc73a2b41f0d103a39952733a3aa https://pubmed.ncbi.nlm.nih.gov/17033724 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0b9dcc73a2b41f0d103a39952733a3aa |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 0171967X 14320827 |
|---|