Low-profile stent system for treatment of atherosclerotic renal artery stenosis: The GREAT trial
| العنوان: | Low-profile stent system for treatment of atherosclerotic renal artery stenosis: The GREAT trial |
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| المؤلفون: | Nic J. G. M. Veeger, Geir Hafsahl, Marc Sapoval, Markus Zähringer, Aly Talen, Claudio Rabbia, Louis Boyer, Claudio Vignali, Peter M. T. Pattynama, Jean Paul Beregi, Geert Maleux, Werner Jaschke, Mark Downes, Malgorzata Szczerbo-Trojanowska |
| المساهمون: | Radiology & Nuclear Medicine |
| المصدر: | Journal of Vascular and Interventional Radiology, 16(9), 1195-1202. Elsevier Inc. Journal of Vascular and Interventional Radiology, 16(9), 1195-1202. ELSEVIER SCIENCE INC |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, BALLOON ANGIOPLASTY, medicine.medical_treatment, MULTICENTER, Blood Pressure, Renal artery stenosis, Kidney, Postoperative Complications, Restenosis, HYPERTENSIVE PATIENTS, Clinical endpoint, Prospective Studies, medicine.diagnostic_test, Middle Aged, Europe, Treatment Outcome, Creatinine, PLACEMENT, Female, Stents, Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Revascularization, Renal Artery Obstruction, Lesion, Blood Vessel Prosthesis Implantation, medicine.artery, medicine, Humans, Radiology, Nuclear Medicine and imaging, Renal artery, Antihypertensive Agents, Device Removal, Vascular Patency, METAANALYSIS, Aged, business.industry, PALMAZ STENT, Stent, equipment and supplies, medicine.disease, Myocardial Contraction, Surgery, Radiography, Angiography, business, Angioplasty, Balloon, Follow-Up Studies |
| الوصف: | PURPOSE: The Palmaz Genesis Peripheral Stainless Steel Balloon Expandable Stent in Renal Artery Treatment (GREAT) Trial was designed to assess the safety and performance of a low-profile stent for the treatment of obstructive renal artery disease by looking at 6-month renal artery patency uniformly analyzed by a Core Lab.MATERIALS AND METHODS: Fifty-two consecutive patients (mean age, 63.7 years) were successfully treated with the Palmaz Genesis Peripheral Stent (Cordis, Miami, FL) on the Slalom 0.018-inch Delivery System (Cordis Europe N.V., Oosteinde 8, NLO-9301 LJ Roden, The Netherlands) at 11 investigational centers. Patients with severe renal failure and > 8-mm renal artery were excluded. Primary endpoint was angiographic determination of in-stent percent diameter stenosis at 6 months. Fifty-one patients were treated with one stent, one patient was treated with two stents to cover the complete lesion.RESULTS: Mean percentage diameter stenosis before renal angioplasty was 68.2% +/- 12.0%. No stent implantation failure, displacement, need for additional stent implantation, or procedural complication was observed. Six-month angiography was performed in 41 of 52 patients (79%) resulting in a mean in-stent percent diameter stenosis or Quantitative Vessel analysis (QVA) at 6 months of 23.9%. The in-stent binary (percent diameter stenosis > 50%) restenosis rate at 6 months was 14.3%. No fatal events occurred up to 6 months after implantation. Major adverse events occurred in five patients: four patients (7.7%) required a revascularization and one patient (1.9%) experienced a cerebrovascular event, which regressed spontaneously.CONCLUSIONS: The Palmaz Genesis stent (Cordis) provides good results for renal artery stent placement, with an in-stent binary restenosis rate (percent diameter stenosis > 50%) at 6 months of 14.3% as determined with angiography. |
| تدمد: | 1051-0443 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba194334a0c81cc0646cbc4c70c30c9 https://doi.org/10.1097/01.rvi.0000171765.67665.d3 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....0ba194334a0c81cc0646cbc4c70c30c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10510443 |
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