Cutoff values of acoustic radiation force impulse two-location measurements in different etiologies of liver fibrosis
| العنوان: | Cutoff values of acoustic radiation force impulse two-location measurements in different etiologies of liver fibrosis |
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| المؤلفون: | Dar-In Tai, Wan-Ting Yu, Jennifer Tai, Shiu-Feng Huang, Po-Hsiang Tsui, Tse-Hwa Hsu, Yung-Liang Wan |
| المصدر: | Journal of Medical Ultrasound, Vol 27, Iss 3, Pp 130-134 (2019) Journal of Medical Ultrasound |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | METAVIR Fibrosis Score, medicine.medical_specialty, HBsAg, Cirrhosis, lcsh:Medical technology, Receiver operating characteristic, Acoustic radiation force impulse, business.industry, hepatic steatosis, Fatty liver, medicine.disease, Gastroenterology, lcsh:R855-855.5, Fibrosis, Internal medicine, medicine, Etiology, Cutoff, chronic hepatitis C, Radiology, Nuclear Medicine and imaging, Original Article, chronic hepatitis B, business, liver fibrosis |
| الوصف: | Background: Acoustic radiation force impulse (ARFI) imaging is a popular modality to measure liver fibrosis. ARFI selects optimal locations for measurement under imaging guiding. However, there are concerns on study locations and observers bias. To decrease the variations, ARFI at two locations was measured with standardized protocol. This study attempted to establish its cutoff values according to Metavir fibrosis score in different etiologies. Methods: A consecutive series of patients who received liver histology study were prospectively enrolled. All cases had hemogram, liver biochemistry, viral markers, and ARFI two-location measurements within 4 weeks of histology study. A standardized protocol was performed by single technologist. We excluded patients with alanine aminotransferase >5x upper limit normal. Results: Five hundred and ten patients that included 153 seronegative for both HBsAg and anti-HCV Non-B non-C (NBNC), 33 autoimmune liver diseases (AILD), 261 chronic hepatitis B (CHB), and 63 chronic hepatitis C (CHC) were enrolled. About 83% of NBNC patients had fat cell >5%. For diagnosis of liver cirrhosis, the area under receiver operating characteristic curve of NBNC, AILD, CHB, and CHC groups was 0.937, 0.929, 0.784, and 0.937; the cutoff values for mean ARFI were 1.788, 2.095, 1.455, and 1.710 m/s, respectively. The sensitivity and specificity are both over 0.818 for patients with nonalcoholic fatty liver diseases, CHC, and AILD, but the corresponding data are only 0.727–0.756 in CHB. The Fibrosis-4 Score is as good as ARFI on fibrosis assessment in NBNC. Conclusion: The performance of ARFI two-location measurement is excellent in NBNC, AILD, and CHC, but is only satisfactory in CHB. |
| اللغة: | English |
| تدمد: | 2212-1552 0929-6441 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0babfe3212185d9f90778740166cd2f6 http://www.jmuonline.org/article.asp?issn=0929-6441;year=2019;volume=27;issue=3;spage=130;epage=134;aulast=Hsu |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0babfe3212185d9f90778740166cd2f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22121552 09296441 |
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