Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation
| العنوان: | Ganglion Cell Complex in Early and Intermediate Age-Related Macular Degeneration: Evidence by SD-OCT Manual Segmentation |
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| المؤلفون: | Pedro Camacho, Liliana P. Paris, Marco Dutra-Medeiros |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Retinal Ganglion Cells, Time Factors, genetic structures, Visual Acuity, Severity of Illness Index, Macular Degeneration, 0302 clinical medicine, Nerve Fibers, Aged, 80 and over, medicine.diagnostic_test, General Medicine, Middle Aged, Sensory Systems, Ganglion, medicine.anatomical_structure, Disease Progression, Manual segmentation, Female, Tomography, Optical Coherence, medicine.medical_specialty, Ganglion cell layer, Cell complex, 03 medical and health sciences, Optical coherence tomography, Age related, Ophthalmology, Ganglion cell complex, medicine, Spectral-domain optical coherence tomography, Humans, Aged, Retrospective Studies, Receiver operating characteristic, business.industry, Age-related macular degeneration, Macular degeneration, medicine.disease, eye diseases, 030104 developmental biology, ROC Curve, 030221 ophthalmology & optometry, sense organs, Visual Fields, business, Follow-Up Studies |
| الوصف: | Purpose: To evaluate ganglion cell layer (GCL) and ganglion cell complex (GCC) thickness manually by spectral-domain optical coherence tomography in subjects with early and intermediate age-related macular degeneration (AMD) in 12 locations on the horizontal meridian. Methods: A total of 450 eyes (specifically, 246 eyes classified as having early/intermediate AMD plus 204 control eyes) were studied. Mann-Whitney U and Kruskal-Wallis tests were used to compare values between the healthy controls and the AMD group and also between the subgroups under study. Diagnostic performance was also compared calculating the areas under the receiver operating characteristic curve. Results: The manual layer segmentation showed clear boundaries between the GCL and the GCC. It was in the temporal GCC that more changes were found. Conclusions: The GCC, especially in the temporal region, allowed the discrimination of differences between various subgroups that have faint variations as well as between early AMD and the first signs of aging. |
| تدمد: | 1423-0267 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be3dcba40e63cc5173eef4e4e6dcf30 https://pubmed.ncbi.nlm.nih.gov/28505617 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0be3dcba40e63cc5173eef4e4e6dcf30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230267 |
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