Clinical Outcome of Isolated Serous Tubal Intraepithelial Carcinomas (STIC)
| العنوان: | Clinical Outcome of Isolated Serous Tubal Intraepithelial Carcinomas (STIC) |
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| المؤلفون: | Richard R. Barakat, Fanny Dao, Ginger J. Gardner, Kay J. Park, Ebunoluwa Otegbeye, Douglas A. Levine, Stephanie L. Wethington, Noah D. Kauff, Nadeem R. Abu-Rustum, Robert A. Soslow, Yukio Sonoda, Carol L. Brown |
| المصدر: | International Journal of Gynecologic Cancer. 23:1603-1611 |
| بيانات النشر: | BMJ, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Serous carcinoma, medicine.medical_treatment, Genes, BRCA2, Genes, BRCA1, Article, Fallopian Tube Neoplasms, Humans, Medicine, Genetic Predisposition to Disease, Clinical significance, Family history, Germ-Line Mutation, Aged, Retrospective Studies, Gynecology, Hysterectomy, business.industry, BRCA mutation, Obstetrics and Gynecology, Serous Tubal Intraepithelial Carcinoma, Middle Aged, Prognosis, medicine.disease, Cystadenocarcinoma, Serous, Serous fluid, Oncology, Female, Radiology, business, Ovarian cancer, Carcinoma in Situ, Follow-Up Studies |
| الوصف: | ObjectiveRisk-reducing salpingo-oophorectomy (RRSO) is recommended for women with BRCA mutation due to increased risk of pelvic serous carcinoma. Serous tubal intraepithelial carcinoma (STIC) is a pathologic finding of unknown clinical significance. This study evaluates the clinical outcome of patients with isolated STIC.Materials/MethodsWe retrospectively reviewed the medical records of consecutive patients with a germline BRCA1/2 mutation or a high-risk personal or family history of ovarian cancer who underwent RRSO between January 2006 and June 2011. All patients had peritoneal washings collected. All surgical specimens were assessed using the sectioning and extensively examining the fimbria protocol, with immunohistochemistry when indicated. p53 signature lesions and secretory cell outgrowths were excluded.ResultsOf 593 patients who underwent RRSO, isolated STIC was diagnosed in 12 patients (2%). Five patients (42%) were BRCA1 positive, 5 patients (42%) were BRCA2 positive, and 2 patients (17%) had high-risk family history. Preoperatively, all patients with STIC had normal CA-125 levels and/or pelvic imaging results. Seven patients underwent hysterectomy and omentectomy, 6 patients (46%) had pelvic node dissections, and 5 patients (39%) had para-aortic node dissections. With the exception of positive peritoneal washings in 1 patient, no invasive or metastatic disease was identified. No patient received adjuvant chemotherapy. At median follow-up of 28 months (range, 16–44 months), no recurrences have been identified.ConclusionsAmong the cases of isolated STIC after RRSO reported in the literature, the yield of surgical staging is low, and short-term clinical outcomes are favorable. Peritoneal washings are the most common site of disease spread. Individualized management is warranted until additional data become available. |
| تدمد: | 1525-1438 1048-891X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf03e7ccf5e8b7c237d3e6ac42288a0 https://doi.org/10.1097/igc.0b013e3182a80ac8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0bf03e7ccf5e8b7c237d3e6ac42288a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251438 1048891X |
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