X-to-autosome expression and msl-2 transcript abundance correlate among Drosophila melanogaster somatic tissues
| العنوان: | X-to-autosome expression and msl-2 transcript abundance correlate among Drosophila melanogaster somatic tissues |
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| المؤلفون: | Steven P. Vensko, Eric A. Stone |
| المصدر: | PeerJ, Vol 3, p e771 (2015) PeerJ |
| بيانات النشر: | PeerJ Inc., 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | endocrine system, Somatic cell, Somatic Cell Genetics, lcsh:Medicine, General Biochemistry, Genetics and Molecular Biology, MSL complex, Gene expression, Genetics, Dosage compensation, H4K16Ac, biology, General Neuroscience, fungi, lcsh:R, Computational Biology, Genomics, General Medicine, biology.organism_classification, Dosage compensation complex, Chromatin, Drosophila melanogaster, General Agricultural and Biological Sciences, Male-Specific Lethal complex |
| الوصف: | In Drosophila melanogaster, the male-specific lethal (MSL) complex has been studied extensively for its role in upregulating male X-linked genes. Recent advances in high-throughput technologies have improved our understanding of how the MSL complex mediates dosage compensation through chromosome-wide chromatin modifications. Most studies, however, have focused on cell line models that cannot reflect any potential heterogeneity of in vivo dosage compensation. Comparisons between cell line and organismal gene-level dosage compensation upregulation suggest the possibility of variation in MSL complex activity among somatic tissues. We hypothesize the degree, up to but not exceeding 2-fold, to which the MSL complex upregulates male X-linked genes varies quantitatively by tissue type. In this model, MSL complex abundance acts as a rheostat to control the extent of upregulation. Using publicly available expression data, we provide evidence for our model in Drosophila somatic tissues. Specifically, we find X-to-autosome expression correlates with the tissue-specific expression of msl-2 which encodes an essential male-specific component of the MSL complex. This result suggests MSL complex mediated dosage compensation varies quantitatively by tissue type. Furthermore, this result has consequences for models explaining the organismal-scale molecular and evolutionary consequences of MSL-mediated dosage compensation. |
| اللغة: | English |
| تدمد: | 2167-8359 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1a4503e7580f18b9dfd99e608ee7de https://peerj.com/articles/771.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0c1a4503e7580f18b9dfd99e608ee7de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21678359 |
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