LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling
| العنوان: | LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling |
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| المؤلفون: | Xinyang, Wu, Lijun, Pu, Wei, Chen, Qi, Zhao, Geping, Wu, Di, Li, Hongyan, Zhu |
| المصدر: | Immunopharmacology and Immunotoxicology. 44:510-518 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Inflammation, Lipopolysaccharides, Pharmacology, Morpholines, Immunology, General Medicine, Toxicology, Rats, Endotoxins, Uveitis, Phosphatidylinositol 3-Kinases, Chromones, Animals, Cytokines, Immunology and Allergy, Proto-Oncogene Proteins c-akt |
| الوصف: | Uveitis is a prevalent inflammatory eye disease that damages the vision of patients and even leads to blindness. LY294002, an inhibitor of PI3K, was reported to suppress the inflammation and alleviate the progression of many diseases. However, the function of LY294002 in uveitis is unclear.This study aimed to explore the function of LY294002 in endotoxin-induced uveitis (EIU).EIU rat models were establishedLY294002 alleviated ocular inflammation and decreased inflammatory cell infiltration in the anterior chamber, iris, ciliary body, vitreous cavity, and retina of EIU rats. LY294002 decreased the concentration of proinflammatory cytokines INF-γ, IL-17, IL-6, TNF-α, and IL-1β in aqueous humor and their expression in the ICB and retina of EIU rats. LY294002 downregulated JAK3 expression in EIU rats. LY294002 inhibited p-PI3K and p-Akt expression in EIU rats and restrained Akt translocation from cytoplasm to cell membrane in LPS-treated rMC-1 cells.LY294002 ameliorates inflammation in EIU by downregulating JAK3 and inactivating the PI3K/Akt signaling. |
| تدمد: | 1532-2513 0892-3973 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9e1f4cfd0003bc02939e4d421945a5 https://doi.org/10.1080/08923973.2022.2055565 |
| رقم الأكسشن: | edsair.doi.dedup.....0c9e1f4cfd0003bc02939e4d421945a5 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15322513 08923973 |
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