أعرض في EDS

Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients

التفاصيل البيبلوغرافية
العنوان: Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients
المؤلفون: Hui Lin, Xin Yi, Xiaoxiao Fan, Yili Dai, Daizhan Zhou, Yirun Li, Guoqiao Chen, Binghua Dai, Bin Cui, Shengxi Jin
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 11, Pp 630-643 (2020)
Neoplasia (New York, N.Y.)
بيانات النشر: Elsevier BV, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Adult, Epigenomics, Male, 0301 basic medicine, Original article, Cancer Research, Carcinoma, Hepatocellular, Apoptosis, Tumor initiation, Biology, lcsh:RC254-282, Epigenesis, Genetic, Epigenome, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, medicine, Humans, DAC, decitabine, PVTT, portal vein tumor thrombosis, Promoter Regions, Genetic, Gene, Aged, Cell Proliferation, Gene Expression Profiling, DMPs, differentially methylated positions, Computational Biology, Thrombosis, Methylation, DNA Methylation, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, DNA methylation, Cancer research, Female, Transcriptome, HCC, hepatocellular carcinoma
الوصف: Aberrant methylation is a hallmark of hepatocellular carcinoma and plays an important role in tumor initiation and progression. However, the epigenome-wide methylation patterns of portal vein tumor thrombosis (PVTTs) have not been fully explored. Here, we performed epigenome-wide DNA methylation of adjacent normal tissues (ANTs), paired tumor tissues and paired PVTTs using an Infinium HumanMethylation450 array (n = 11) and conducted the Sequenom EpiTYPER assays to confirm the aberrantly methylated genes. MTS and apoptosis assay were used to assess the synergistic effect of two drugs on the HCC cell lines. We found the mean global methylation levels of HCC tissues and PVTTs were significantly lower than ANTs (P 10%, P
تدمد: 1476-5586
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9f3e69d183fe561e363a66db6a15fc
https://doi.org/10.1016/j.neo.2020.09.007
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....0c9f3e69d183fe561e363a66db6a15fc
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14765586