Simulation analysis to test the influence of model adequacy and data structure on the estimation of genetic parameters for traits with direct and maternal effects
| العنوان: | Simulation analysis to test the influence of model adequacy and data structure on the estimation of genetic parameters for traits with direct and maternal effects |
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| المؤلفون: | Jacques Bouix, Virginie Clément, Etienne Verrier, Eric Hanocq, Bernard Bibé, Jean-Michel Elsen, Eduardo Manfredi |
| المساهمون: | Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Station de Génétique Quantitative et Appliquée (SGQA) |
| المصدر: | Genetics Selection Evolution, Vol 33, Iss 4, Pp 369-395 (2001) Genetics Selection Evolution Genetics Selection Evolution, BioMed Central, 2001, 33, pp.369-395 Genetics, Selection, Evolution : GSE Genetics Selection Evolution (33), 369-395. (2001) Genetics Selection Evolution, BioMed Central, 2001, 33 (4), pp.369-395. ⟨10.1051/gse:2001123⟩ HAL |
| بيانات النشر: | BMC, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | modèle animal, héritabilité, Statistics as Topic, Paternity, variance, Statistics, méthode statistique, genetic parameters, chromosome sexuel, Genetics(clinical), génétique quantitative, ComputingMilieux_MISCELLANEOUS, lcsh:SF1-1100, Genetics, 0303 health sciences, Estimation theory, Maternal effect, 04 agricultural and veterinary sciences, General Medicine, simulation, Random effects model, Phenotype, maternal effects, Female, simulations, lcsh:QH426-470, Mothers, Biology, paramètre génétique, Genetic correlation, connectedness, 03 medical and health sciences, Bias, Genetic variation, Animals, Computer Simulation, Selection, Genetic, Ecology, Evolution, Behavior and Systematics, Selection (genetic algorithm), modélisation, 030304 developmental biology, [SDV.GEN]Life Sciences [q-bio]/Genetics, Models, Genetic, Research, animal model, 0402 animal and dairy science, Genetic Variation, Reproducibility of Results, Quantitative genetics, Models, Theoretical, Heritability, 040201 dairy & animal science, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, lcsh:Genetics, technique analytique, Animal Science and Zoology, lcsh:Animal culture |
| الوصف: | International audience; Simulations were used to study the influence of model adequacy and data structure on the estimation of genetic parameters for traits governed by direct and maternal effects. To test model adequacy, several data sets were simulated according to different underlying genetic assumptions and analysed by comparing the correct and incorrect models. Results showed that omission of one of the random effects leads to an incorrect decomposition of the other components. If maternal genetic effects exist but are neglected, direct heritability is overestimated, and sometimes more than double. The bias depends on the value of the genetic correlation between direct and maternal effects. To study the influence of data structure on the estimation of genetic parameters, several populations were simulated, with different degrees of known paternity and different levels of genetic connectedness between flocks. Results showed that the lack of connectedness affects estimates when flocks have different genetic means because no distinction can be made between genetic and environmental differences between flocks. In this case, direct and maternal heritabilities are under-estimated, whereas maternal environmental effects are overestimated. The insufficiency of pedigree leads to biased estimates of genetic parameters. |
| وصف الملف: | application/pdf |
| اللغة: | German |
| تدمد: | 1297-9686 0999-193X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb2a262b9cf9efd5c02e057c1e44bff http://www.gsejournal.org/content/33/4/369 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0cb2a262b9cf9efd5c02e057c1e44bff |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 12979686 0999193X |
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