Virtual clinical trial to compare cancer detection using combinations of 2D mammography, digital breast tomosynthesis and synthetic 2D imaging
| العنوان: | Virtual clinical trial to compare cancer detection using combinations of 2D mammography, digital breast tomosynthesis and synthetic 2D imaging |
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| المؤلفون: | Premkumar Elangovan, Rosalind M. Given-Wilson, Chantal Van Ongeval, Lesley Cockmartin, Matthew G. Wallis, Melissa Mitchell, Emma L. Thomson, Alistair Mackenzie, Kenneth C. Young, David R. Dance, Louise Wilkinson, Lucy M. Warren |
| المصدر: | European Radiology. 32:806-814 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Digital mammography, IMAGES, DBT, Cancer detection, SYNTHESIZED 2-DIMENSIONAL MAMMOGRAPHY, IMPLEMENTATION, Medicine, Mammography, Radiology, Nuclear Medicine and imaging, POPULATION, Cancer, Neuroradiology, Science & Technology, 2-VIEW, medicine.diagnostic_test, business.industry, Radiology, Nuclear Medicine & Medical Imaging, ALGORITHMS, General Medicine, Digital Breast Tomosynthesis, PERFORMANCE, medicine.disease, Tomosynthesis, SIMULATION, Screening, Imaging technology, Radiology, business, Life Sciences & Biomedicine, Calcification |
| الوصف: | OBJECTIVES: This study was designed to compare the detection of subtle lesions (calcification clusters or masses) when using the combination of digital breast tomosynthesis (DBT) and synthetic mammography (SM) with digital mammography (DM) alone or combined with DBT. METHODS: A set of 166 cases without cancer was acquired on a DBT mammography system. Realistic subtle calcification clusters and masses in the DM images and DBT planes were digitally inserted into 104 of the acquired cases. Three study arms were created: DM alone, DM with DBT and SM with DBT. Five mammographic readers located the centre of any lesion within the images that should be recalled for further investigation and graded their suspiciousness. A JAFROC figure of merit (FoM) and lesion detection fraction (LDF) were calculated for each study arm. The visibility of the lesions in the DBT images was compared with SM and DM images. RESULTS: For calcification clusters, there were no significant differences (p > 0.075) in FoM or LDF. For masses, the FoM and LDF were significantly improved in the arms using DBT compared to DM alone (p < 0.001). On average, both calcification clusters and masses were more visible on DBT than on DM and SM images. CONCLUSIONS: This study demonstrated that masses were detected better with DBT than with DM alone and there was no significant difference (p = 0.075) in LDF between DM&DBT and SM&DBT for calcifications clusters. Our results support previous studies that it may be acceptable to not acquire digital mammography alongside tomosynthesis for subtle calcification clusters and ill-defined masses. KEY POINTS: • The detection of masses was significantly better using DBT than with digital mammography alone. • The detection of calcification clusters was not significantly different between digital mammography and synthetic 2D images combined with tomosynthesis. • Our results support previous studies that it may be acceptable to not acquire digital mammography alongside tomosynthesis for subtle calcification clusters and ill-defined masses for the imaging technology used. ispartof: EUROPEAN RADIOLOGY vol:32 issue:2 pages:806-814 ispartof: location:Germany status: published |
| وصف الملف: | Print-Electronic |
| تدمد: | 1432-1084 0938-7994 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb46982442d526e5cb25aa0c7d3703d https://doi.org/10.1007/s00330-021-08197-x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0cb46982442d526e5cb25aa0c7d3703d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321084 09387994 |
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