Sex-Specific Associations Between Bipolar Disorder Pharmacological Maintenance Therapies and Inpatient Rehospitalizations: A 9-Year Swedish National Registry Study
| العنوان: | Sex-Specific Associations Between Bipolar Disorder Pharmacological Maintenance Therapies and Inpatient Rehospitalizations: A 9-Year Swedish National Registry Study |
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| المؤلفون: | Dragos C. Ragazan, Jonas Eberhard, Jonas Berge |
| المصدر: | Frontiers in Psychiatry, Vol 11 (2020) Frontiers in Psychiatry |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Olanzapine, rehospitalization, medicine.medical_specialty, pharmacoepidemiogy, lcsh:RC435-571, sex-based analysis, maintenance therapy, Population, 03 medical and health sciences, 0302 clinical medicine, Maintenance therapy, sex-based differences, Internal medicine, lcsh:Psychiatry, medicine, Ziprasidone, Bipolar disorder, education, Original Research, Psychiatry, bipolar disorder, education.field_of_study, register, Risperidone, business.industry, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Quetiapine, Aripiprazole, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Background: Long-term pharmacological maintenance therapy is often essential among people with bipolar disorder to reduce the need for inpatient care. Sex-specific responses to maintenance therapies are expected but remain largely unknown. Here, we examined for sex-specific associations between common maintenance therapies for bipolar disorder with inpatient rehospitalizations following patients' index discharges during 2006–2014. Methods: Population-based data on maintenance therapies and rehospitalizations were extracted from Swedish national registries. We adopted the within-individual design to compare the time on- vs. off- maintenance therapy for males and females, respectively. Extended stratified Cox proportional hazards regression models were employed to quantify the rate of rehospitalization as a function of common maintenance drugs and other important time-varying control variables. Results: Our primary analysis included 22,681 bipolar disorder rehospitalizations by 6,400 males and 9,588 (60.0%) females over an observation time of 62,813 person-years. The time spent on- vs. off- maintenance lithium, lamotrigine, quetiapine, or olanzapine was statistically significant upon adjustment among either sex for reducing the rate of bipolar rehospitalizations. Adjusted sex-specific statistically significant associations were also observed. Among females, the time on- (vs. off-) long-acting injectable risperidone reduced the rate of bipolar rehospitalizations by 73% (56–84%), carbamazepine by 44% (18–62%), aripiprazole by 29% (13–42%), and valproate by 23% (11–33%); whereas among males, ziprasidone by 65% (41–79%). Conclusion: The effectiveness of most maintenance therapies is generally comparable and uniform among both males and females. Despite some statistically significant sex-specific associations, estimates for each drug were fairly consistent between sexes. |
| اللغة: | English |
| تدمد: | 1664-0640 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d18979b92b11748581df12d6ad8575b https://www.frontiersin.org/articles/10.3389/fpsyt.2020.598946/full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0d18979b92b11748581df12d6ad8575b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16640640 |
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