Formulation and Evaluation of Sintered Floating Tablets of Cefpodoxime Proxetil
| العنوان: | Formulation and Evaluation of Sintered Floating Tablets of Cefpodoxime Proxetil |
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| المؤلفون: | Naseeb Basha Shaik, Kishore Chittimalli, Latha Kukati, Shailaja Thoudoju |
| المصدر: | Turkish Journal of Pharmaceutical Sciences, Vol 15, Iss 3, Pp 278-290 (2018) Turkish Journal of Pharmaceutical Sciences |
| بيانات النشر: | Galenos Yayinevi, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Cefpodoxime proxetil, Materials science, gastro-retentive floating tablets, sintering technique, lcsh:RS1-441, Pharmaceutical Science, Controlled release, controlled material, Bioavailability, lcsh:Pharmacy and materia medica, Matrix (chemical analysis), chemistry.chemical_compound, Camphor, chemistry, Acetone, Molecular Medicine, Original Article, Locust bean gum, Solubility, Dissolution, Nuclear chemistry |
| الوصف: | Objectives To develop sintered floating tablets of CP using locust bean gum as a release-controlling material. CP is an orally- administered, extended-spectrum, semi-synthetic antibiotic of the cephalosporin class. Materials and methods CP has a short elimination half-life, possesses high solubility, chemical, enzymatic stability and absorption profiles in acidic pH, which makes it a suitable candidate for formulation in a gastro-retentive dose form for improved bioavailability. Camphor was used to get the desired floating properties. The prepared CP floating tablets were subjected to sintering, where the cross linkage within the polymeric structure was increased by exposing the tablets to acetone vapors. The advantage with sintering is that prolonged drug release can be attained at low hardness and low concentrations of polymers. Results The prepared tablets were evaluated and found to have acceptable physicochemical properties. Formulation S2 containing locust bean gum: drug (0.3:1.0) and camphor (10% w/w), which was exposed to acetone vapors for a period of 6 hrs showed optimum floating properties and a better dissolution profile i.e. 97.3% in 12 hrs. Hence, formulation S2 was considered as the optimized formulation. The in vitro release data of the optimized formulation was treated with mathematical equations and the drug release followed zero-order kinetics (0.9599) with an anomalous transport mechanism (0.5331). Conclusion Based on the results, it can be concluded that sintered floating matrix tablets of CP containing locust bean provides a better choice for controlled release. |
| تدمد: | 2148-6247 1304-530X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1ac8d291f5b465071c7b5c17307953 https://doi.org/10.4274/tjps.59454 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0d1ac8d291f5b465071c7b5c17307953 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21486247 1304530X |
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