Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses
| العنوان: | Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses |
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| المؤلفون: | Beatris Mastelic-Gavillet, Lucas Esteves Cardozo, Frederico Moraes Ferreira, Maria Vono, Claire-Anne Siegrist, Patrícia Gonzalez-Dias, Paul-Henri Lambert, Helder I. Nakaya |
| المصدر: | Frontiers in Immunology, Vol 10 (2019) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Frontiers in Immunology, Vol. 10 (2019) P. 1845 Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Aging, Germinal Center/cytology/immunology, Lymphopoiesis/genetics, T-Lymphocytes, Cell, ddc:616.07, Adaptive Immunity, Inbred C57BL, CXCR5, Transcriptome, ANTÍGENOS, Mice, 0302 clinical medicine, Immunologic, Follicular phase, Immunology and Allergy, Innate, STAT4, Original Research, Aging/immunology, Interleukin-13, ddc:618, Effector, Lymphopoiesis, Newborn/immunology, Helper-Inducer/immunology, Interleukin-13/metabolism, T-Lymphocytes, Helper-Inducer, vaccines, BCL6, medicine.anatomical_structure, lcsh:Immunologic diseases. Allergy, Immunology, Biology, 03 medical and health sciences, Th2 Cells, Adjuvants, Immunologic, adjuvant, medicine, Animals, Adjuvants, Th2 Cells/cytology/immunology, Immunity, Germinal center, Germinal Center, neonates, Immunity, Innate, Mice, Inbred C57BL, 030104 developmental biology, Animals, Newborn, T follicular helper cells, lcsh:RC581-607, transcriptional profile analysis, 030215 immunology |
| الوصف: | T follicular helper (Tfh) cells have emerged as a critical limiting factor for controlling the magnitude of neonatal germinal center (GC) reactions and primary vaccine antibody responses. We compared the functional attributes of neonatal and adult Tfh cells at the transcriptomic level and demonstrated that the Tfh cell program is well-initiated in neonates although the Tfh gene-expression pattern (i.e., CXCR5, IL-21, BCL6, TBK1, STAT4, ASCL2, and c-MAF) is largely underrepresented as compared to adult Tfh cells. Importantly, we identified a TH2-bias of neonatal Tfh cells, with preferential differentiation toward short-lived pre-Tfh effector cells. Remarkably, adjuvantation with CpG-ODNs redirect neonatal pre-Tfh cells toward committed GC-Tfh cells, as illustrated by increased expression of Tfh signature genes and reduced expression of TH2-related genes. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d304b56e7a2902a69eb9e89eefb753d https://www.frontiersin.org/article/10.3389/fimmu.2019.01845/full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0d304b56e7a2902a69eb9e89eefb753d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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