Technical Note: A safe, cheap, and easy-to-use isotropic diffusion MRI phantom for clinical and multicenter studies
| العنوان: | Technical Note: A safe, cheap, and easy-to-use isotropic diffusion MRI phantom for clinical and multicenter studies |
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| المؤلفون: | Pim Pullens, Jan Sijbers, Andrew I R Maas, Paul M. Parizel, Piet Bladt |
| المصدر: | Medical physics |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Time Factors, Correlation coefficient, Quality Assurance, Health Care, Calibration curve, Imaging phantom, 030218 nuclear medicine & medical imaging, Diffusion, 03 medical and health sciences, 0302 clinical medicine, Calibration, Effective diffusion coefficient, Medicine, Humans, Multicenter Studies as Topic, Diffusion (business), Computer. Automation, business.industry, Phantoms, Imaging, Temperature, Brain, Povidone, Reproducibility of Results, General Medicine, Models, Theoretical, White Matter, 3. Good health, Solutions, Diffusion Magnetic Resonance Imaging, business, Nuclear medicine, Quality assurance, 030217 neurology & neurosurgery, Algorithms, Diffusion MRI |
| الوصف: | Purpose: Since Diffusion Weighted Imaging (DWI) data acquisition and processing are not standardized, substantial differences in DWI derived measures such as Apparent Diffusion Coefficient (ADC) may arise which are related to the acquisition or MRI processing method, but not to the sample under study. Quality assurance using a standardized test object, or phantom, is a key factor in standardizing DWI across scanners. Methods: Current diffusion phantoms are either complex to use, not available in larger quantities, contain substances unwanted in a clinical environment, or are expensive. A diffusion phantom based on a polyvinylpyrrolidone (PVP) solution, together with a phantom holder, is presented and compared to existing diffusion phantoms for use in clinical DWI scans. An ADC vs. temperature calibration curve was obtained. Results: ADC of the phantom (808 to 857 +/- 0.2 mm(2)/s) is in the same range as ADC values found in brain tissue. ADC measurements are highly reproducible across time with an intra-class correlation coefficient of > 0.8. ADC as function of temperature (in Kelvin) can be estimated as ADC(m)(T) = [expd(-7.09).exp (-2903.8 (1/T - 1/293.55))] with a total uncertainty (95% confidence limit) of +/- 1.7%. Conclusion: We present an isotropic diffusion MRI phantom, together with its temperature calibration curve, that is easy-to-use in a clinical environment, cost-effective, reproducible to produce, and that contains no harmful substances. (C) 2017 American Association of Physicists in Medicine |
| تدمد: | 2473-4209 0094-2405 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5ef1ea8dfb0d3e3fc58d7ff8b741b2 https://pubmed.ncbi.nlm.nih.gov/28079257 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0d5ef1ea8dfb0d3e3fc58d7ff8b741b2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24734209 00942405 |
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