Preparation and Adsorption Properties of Novel Porous Microspheres with Different Concentrations of Bilirubin
| العنوان: | Preparation and Adsorption Properties of Novel Porous Microspheres with Different Concentrations of Bilirubin |
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| المؤلفون: | Yao Rao, Junna Zhu, Wei Lu, Meili Yu, Rui Su, Chenyang Dai, Guangrong Jin, Wei Hou, Aiqing Ji, Xiaomin Shen |
| المصدر: | Blood Purification. 42:104-110 |
| بيانات النشر: | S. Karger AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Bilirubin, Kinetics, Biocompatible Materials, 02 engineering and technology, Microsphere, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adsorption, Porous microspheres, Humans, Particle Size, Porosity, Chromatography, Proteins, Hematology, General Medicine, 021001 nanoscience & nanotechnology, Microspheres, Perfusion, chemistry, Nephrology, 030211 gastroenterology & hepatology, Particle size, 0210 nano-technology |
| الوصف: | Background: Plasma perfusion was widely used to clear toxic substances of plasma. Particle size and uniformity of adsorbent microspheres also affect the absorption rate. Methods: Conventional suspension polymerization was improved using a pre-dispersion homogenizer to obtain novel adsorbent microspheres, named ERM-0100. Microsphere-related characteristics and attributes were analysed. Result: The ERM-0100 microspheres efficiently adsorbed different bilirubin concentrations, with a maximum rate of 59.72 ± 1.08%. At high bilirubin concentrations, ERM-0100 exhibited similar adsorption rate with BRS350 and BS330 (p = 0.303, p = 1.000, relatively), and higher than HB-H-6 (p = 0.000). At different concentration, ERM-0100 showed good adsorption performance. The ERM-0100 had no significant adsorption for electrolyte; for TP and ALB, the loss rates of ERM-0100 were 15.65 ± 0.36 and 23.23 ± 1.11%, respectively. In addition, ERM-0100 showed good blood compatibility. Conclusion: The ERM-0100 is a potential biomedical material for plasma perfusion for good effect, less costs and more safety. The microspheres may be coated to reduce its protein adsorption. |
| تدمد: | 1421-9735 0253-5068 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d75749e6848cdc4fa9bafbbf7839f3d https://doi.org/10.1159/000445933 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0d75749e6848cdc4fa9bafbbf7839f3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219735 02535068 |
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