Complete genome sequence and analysis of Wolinella succinogenes

التفاصيل البيبلوغرافية
العنوان: Complete genome sequence and analysis of Wolinella succinogenes
المؤلفون: Folker Meyer, Stephan C. Schuster, Christa Lanz, Claudia Baar, Mark Eppinger, Ramkumar Nandakumar, Guenter Raddatz, Oliver Klimmek, Heike Keller, Andrea Rosinus, Pratik D. Jagtap, Hermann Lederer, Jörg Simon, Burkhard Linke, Roland Gross
بيانات النشر: NATL ACAD SCIENCES, 2003.
سنة النشر: 2003
مصطلحات موضوعية: Glycosylation, epsilon proteobacteria, Molecular Sequence Data, Virulence, Bacterial genome size, Campylobacter jejuni, Genome, Microbiology, Open Reading Frames, Plasmid, Bacterial Proteins, Helicobacter, Gene cluster, pathogenicity, bacterial, Gene, Phylogeny, Genetics, Multidisciplinary, biology, Campylobacter, Biological Sciences, biology.organism_classification, Wolinella, Horizontal gene transfer, Genome, Bacterial, Signal Transduction
الوصف: To understand the origin and emergence of pathogenic bacteria, knowledge of the genetic inventory from their nonpathogenic relatives is a prerequisite. Therefore, the 2.11-megabase genome sequence of Wolinella succinogenes , which is closely related to the pathogenic bacteria Helicobacter pylori and Campylobacter jejuni , was determined. Despite being considered nonpathogenic to its bovine host, W. succinogenes holds an extensive repertoire of genes homologous to known bacterial virulence factors. Many of these genes have been acquired by lateral gene transfer, because part of the virulence plasmid pVir and an N-linked glycosylation gene cluster were found to be syntenic between C. jejuni and genomic islands of W. succinogenes . In contrast to other host-adapted bacteria, W. succinogenes does harbor the highest density of bacterial sensor kinases found in any bacterial genome to date, together with an elaborate signaling circuitry of the GGDEF family of proteins. Because the analysis of the W. succinogenes genome also revealed genes related to soil- and plant-associated bacteria such as the nif genes, W. succinogenes may represent a member of the epsilon proteobacteria with a life cycle outside its host.
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0daa2dc701b67189430f1bd79c170270
https://doi.org/10.1073/pnas.1932838100
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....0daa2dc701b67189430f1bd79c170270
قاعدة البيانات: OpenAIRE