Medical ozone treatment ameliorates the acute distal colitis in rat
| العنوان: | Medical ozone treatment ameliorates the acute distal colitis in rat |
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| المؤلفون: | Necat Yilmaz, Seçkin Özgür Tekeli, Ismail Ustunel, Tuğrul Çakır, Uğur Doğan, Hakan Soylu, Feyza Tekeli, Cebrail Akyüz, Arif Aslaner, Sema Avci, Süleyman Koç |
| المصدر: | Acta Cirurgica Brasileira, Vol 31, Iss 4, Pp 256-263 (2016) Acta Cirúrgica Brasileira v.31 n.4 2016 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 31, Issue: 4, Pages: 256-263, Published: APR 2016 |
| بيانات النشر: | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Vascular Endothelial Growth Factor A, Pathology, Time Factors, medicine.medical_treatment, Interleukin-1beta, Gastroenterology, chemistry.chemical_compound, Random Allocation, 0302 clinical medicine, Edema, Malondialdehyde, Saline, Acetic Acid, biology, Colitis, Immunohistochemistry, Treatment Outcome, 030220 oncology & carcinogenesis, Myeloperoxidase, Acute Disease, medicine.symptom, medicine.medical_specialty, RD1-811, Colon, Inflammation, 03 medical and health sciences, Oxidants, Photochemical, Ozone, Internal medicine, medicine, Animals, Rats, Wistar, Peroxidase, business.industry, Tumor Necrosis Factor-alpha, Reproducibility of Results, medicine.disease, Rats, Disease Models, Animal, 030104 developmental biology, chemistry, biology.protein, Colitis, Ulcerative, Surgery, business, Immunostaining |
| الوصف: | PURPOSE: To investigate the effect of medical ozone treatment on the experimental acute distal colitis in rats. METHODS: Eighteen rats were randomly distributed into three equal groups; control, acute distal colitis (ADC) without and with medical ozone treatment. Rats in the control group were taken saline. ADC was performed by rectal way with 4% acetic acid in groups 2 and 3, and the group 3 was treated with medical ozone for three weeks both rectally and intraperitoneally. At the twenty second day the distal colons samples were obtained for malondialdehyde and myeloperoxidase, blood samples were obtained to measure the levels of TNF-α and IL-1β levels. Histolopatological examination was evaluated with Ki-67, IL-1β and VEGF immunostaining densities. RESULTS: There was significant increase in tissue MDA, MPO activity, TNF-α and IL-1β after ozone administration. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSIONS: Medical ozone treatment ameliorated the experimental acute distal colitis induced by acetic acid in rats. Its possible effect is by means of decreasing inflammation, edema, and affecting the proliferation and the vascularization. |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 0102-8650 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db2fa67f0606eea32b279427d3f6315 http://www.scielo.br/pdf/acb/v31n4/0102-8650-acb-31-04-00256.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0db2fa67f0606eea32b279427d3f6315 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01028650 |
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