A multicellular rosette-mediated collective dendrite extension
| العنوان: | A multicellular rosette-mediated collective dendrite extension |
|---|---|
| المؤلفون: | Ismar Kovacevic, Maxwell G. Heiman, Zhirong Bao, Li Fan |
| المصدر: | eLife eLife, Vol 8 (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Embryo, Nonmammalian, Neurite, QH301-705.5, Science, organogenesis, Dendrite, Biology, General Biochemistry, Genetics and Molecular Biology, Rosette (botany), 03 medical and health sciences, 0302 clinical medicine, dendrite morphogenesis, Cell Movement, collective cell behavior, medicine, Biological neural network, Animals, multicellular rosette, Biology (General), Caenorhabditis elegans, Caenorhabditis elegans Proteins, neuron-epicermis interaction, 030304 developmental biology, 0303 health sciences, Sensory depression, General Immunology and Microbiology, sensory organ, General Neuroscience, Amphid, General Medicine, Dendrites, Dendrite morphogenesis, Cell biology, medicine.anatomical_structure, C. elegans, Medicine, Dendrite extension, Epidermis, Cell Adhesion Molecules, 030217 neurology & neurosurgery, Sensory nerve, Research Article, Neuroscience |
| الوصف: | Coordination of neurite morphogenesis with surrounding tissues is crucial to the establishment of neural circuits, but the underlying cellular and molecular mechanisms remain poorly understood. We show that neurons in a C. elegans sensory organ, called the amphid, undergo a collective dendrite extension to initiate formation of the sensory nerve. The amphid neurons first assemble into a multicellular rosette. The vertex of the rosette, which becomes the dendrite tips, is attached to the anteriorly migrating epidermis and carried to the sensory depression, extruding the dendrites away from the neuronal cell bodies. Multiple adhesion molecules including DYF-7, SAX-7, HMR-1 and DLG-1 function redundantly in rosette-to-epidermis attachment. PAR-6 is localized to the rosette vertex and dendrite tips, and promotes DYF-7 localization and dendrite extension. Our results suggest a collective mechanism of neurite extension that is distinct from the classical pioneer-follower model and highlight the role of mechanical cues from surrounding tissues in shaping neurites. |
| تدمد: | 2050-084X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dea6d33f1a7ac82d4fd77aaba86df63 https://pubmed.ncbi.nlm.nih.gov/30767892 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0dea6d33f1a7ac82d4fd77aaba86df63 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2050084X |
|---|