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Long-Term Outcomes After Atrial Switch Operation for Transposition of the Great Arteries

التفاصيل البيبلوغرافية
العنوان: Long-Term Outcomes After Atrial Switch Operation for Transposition of the Great Arteries
المؤلفون: Craig S. Broberg, Alexandra C. van Dissel, Jessica Minnier, Jamil Aboulhosn, Robert M. Kauling, Salil Ginde, Eric V. Krieger, Fred Rodriguez, Tripti Gupta, Sangeeta Shah, Anitha S. John, Timothy Cotts, W. Aaron Kay, Marissa Kuo, Cindy Dwight, Patricia Woods, Jeremy Nicolarsen, Berardo Sarubbi, Flavia Fusco, Petra Antonova, Susan Fernandes, Jasmine Grewal, Jonathan Cramer, Paul Khairy, Pastora Gallego, Clare O’Donnell, Jane Hannah, Mikael Dellborg, Carla P. Rodriguez-Monserrate, Isabelle Vonder Muhll, Stephen Pylypchuk, Anthony Magalski, Frank Han, Adam M. Lubert, Joseph Kay, Elizabeth Yeung, Jolien Roos-Hesselink, David Baker, David S. Celermajer, Luke J. Burchill, William M. Wilson, Joshua Wong, Shelby Kutty, Alexander R. Opotowsky
المساهمون: Cardiology, Graduate School, ACS - Heart failure & arrhythmias, ACS - Pulmonary hypertension & thrombosis
المصدر: Journal of the American College of Cardiology, 80(10), 951-963. Elsevier Inc.
Journal of the American College of Cardiology, 80(10), 951-963. Elsevier USA
سنة النشر: 2022
مصطلحات موضوعية: Adult, Heart Failure, Male, transposition of the great arteries, QRS duration, Transposition of Great Vessels, atrial arrhythmia, Arteries, congenital heart disease, Arterial Switch Operation, Treatment Outcome, congestive heart failure, systemic right ventricle, Humans, Female, Cardiology and Cardiovascular Medicine, Follow-Up Studies, Retrospective Studies
الوصف: Background: For patients with d-loop transposition of the great arteries (d-TGA) with a systemic right ventricle after an atrial switch operation, there is a need to identify risks for end-stage heart failure outcomes. Objectives: The authors aimed to determine factors associated with survival in a large cohort of such individuals. Methods: This multicenter, retrospective cohort study included adults with d-TGA and prior atrial switch surgery seen at a congenital heart center. Clinical data from initial and most recent visits were obtained. The composite primary outcome was death, transplantation, or mechanical circulatory support (MCS). Results: From 1,168 patients (38% female, age at first visit 29 ± 7.2 years) during a median 9.2 years of follow-up, 91 (8.8% per 10 person-years) met the outcome (66 deaths, 19 transplantations, 6 MCS). Patients experiencing sudden/arrhythmic death were younger than those dying of other causes (32.6 ± 6.4 years vs 42.4 ± 6.8 years; P < 0.001). There was a long duration between sentinel clinical events and end-stage heart failure. Age, atrial arrhythmia, pacemaker, biventricular enlargement, systolic dysfunction, and tricuspid regurgitation were all associated with the primary outcome. Independent 5-year predictors of primary outcome were prior ventricular arrhythmia, heart failure admission, complex anatomy, QRS duration >120 ms, and severe right ventricle dysfunction based on echocardiography. Conclusions: For most adults with d-TGA after atrial switch, progress to end-stage heart failure or death is slow. A simplified prediction score for 5-year adverse outcome is derived to help identify those at greatest risk.
اللغة: English
تدمد: 0735-1097
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3e88356b1af91b2c2b82a79baca5cb
http://www.scopus.com/inward/record.url?scp=85136309311&partnerID=8YFLogxK
حقوق: RESTRICTED
رقم الأكسشن: edsair.doi.dedup.....0e3e88356b1af91b2c2b82a79baca5cb
قاعدة البيانات: OpenAIRE
الوصف
تدمد:07351097